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Department
  • Medicine
    • Research Theme Beyond the Neuron
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    Dr Ian Wilkinson

    University Position
    Associate Professor

    Interests

    My research is clinically orientated and centres on the physiology and pharmacology of the cardiovascular system, and particularly the large arteries and endothelial function. As a clinical pharmacologist, I combine detailed physiological measurement with pharmacological probes to investigate the mechanisms underlying the development of hypertension, arteriosclerosis and ultimately cardiovascular disease. My current research projects include investigating the effect of ageing on the cardiovascular system, and the link between arterial stiffening on cognitive function. I am involved in a number of large collaborative studies including CLEAREST Study and the Caerphilly Heart Study.

    Key Publications

    Publications

    Greater aortic inflammation and calcification in abdominal aortic aneurysmal disease than atherosclerosis: a prospective matched cohort study.

    DOI: http://doi.org/10.1136/openhrt-2019-001141
    Journal: Open Heart
    E-pub date: 1 Aug 2020
    Authors: NV Joshi, M Elkhawad, RO Forsythe, OMB McBride, NK Rajani, JM Tarkin, MM Chowdhury, E Donoghue, JMJ Robson, JR Boyle, TD Fryer, Y Huang, Z Teng, MR Dweck, AA Tawakol, JH Gillard, PA Coughlin, IB Wilkinson, DE Newby, JHF Rudd

    Quantifying normal human brain metabolism using hyperpolarized [1-13C]pyruvate and magnetic resonance imaging.

    DOI: http://doi.org/10.1016/j.neuroimage.2019.01.027
    Journal: Neuroimage
    E-pub date: 1 Apr 2019
    Authors: JT Grist, MA McLean, F Riemer, RF Schulte, SS Deen, F Zaccagna, R Woitek, CJ Daniels, JD Kaggie, T Matys, I Patterson, R Slough, AB Gill, A Chhabra, R Eichenberger, M-C Laurent, A Comment, JH Gillard, AJ Coles, DJ Tyler, I Wilkinson, B Basu, DJ Lomas, MJ Graves, KM Brindle, FA Gallagher

    Functional characterization of common BCL11B gene desert variants suggests a lymphocyte-mediated association of BCL11B with aortic stiffness.

    DOI: http://doi.org/10.1038/s41431-018-0226-z
    Journal: Eur J Hum Genet
    E-pub date: 1 Nov 2018
    Authors: RA Maskari, I Hardege, S Cleary, N Figg, Y Li, K Siew, A Khir, Y Yu, P Liu, I Wilkinson, K O'Shaughnessy, Yasmin

    High Structural Stress and Presence of Intraluminal Thrombus Predict Abdominal Aortic Aneurysm 18F-FDG Uptake: Insights From Biomechanics.

    DOI: http://doi.org/10.1161/CIRCIMAGING.116.004656
    Journal: Circ Cardiovasc Imaging
    E-pub date: 1 Nov 2016
    Authors: Y Huang, Z Teng, M Elkhawad, JM Tarkin, N Joshi, JR Boyle, JR Buscombe, TD Fryer, Y Zhang, AY Park, IB Wilkinson, DE Newby, JH Gillard, JHF Rudd

    Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis.

    DOI: http://doi.org/10.1016/S2213-8587(15)00034-0
    Journal: Lancet Diabetes Endocrinol
    E-pub date: 1 Apr 2015
    Authors: Interleukin 1 Genetics Consortium