Anxiety and anhedonia (loss of pleasure) are major symptoms of psychiatric and neurological disorders with highly variable treatment outcomes. This lecture will highlight their multiple aetiologies within prefrontal and anterior cingulate circuits; as revealed by chemogenetic, neuroimaging, and cardiovascular studies of reward and threat-related behaviors in a non-human primate. The differential sensitivity of these circuits to antidepressants provides translational insights into treatment variability.
Posted on 23/09/2024
