A collaborative work between Harvard University and Cambridge Neuroscience PIs, including Andras Lakatos, Madeline Lancaster, Stephen Eglen, and Ole Paulsen, was published in Cell Reports Methods on 18 November 2024, with Timothy Sit as the first author. The work led by Susanna Mierau in Boston (and affiliated to PDN) describes a novel framework for assessing neuronal network function in CNS models, such as 3D human cerebral organoids. Their precise approach could advance mechanistic and therapeutic studies using human in vitro disease platforms.
Graphical Abstract
The article was also featured on the cover: In this issue, Sit et al. present MEA-NAP, an open-source flexible network analysis pipeline for neuronal 2D and 3D organoid multielectrode recordings. The cover is an artistic impression of the development of hub and non-hub roles in microscale neuronal networks using node cartography. Image credit: Rachael Feord, PhD, and Susanna Mierau, MD, DPhil.
Posted on 04/12/2024