András Lakatos’s lab reports that the knockdown of pleckstrin homology-like domain family A-member 3 diminishes reactive oxygen species release by human spinal astrocytes harbouring the superoxide-dismutase-1 amyotrophic lateral sclerosis mutation and, subsequently, stress response in human spinal neurons. These findings suggest a previously unidentified non-cell-autonomous pathogenic process.
For more information and a link to the paper in Brain Communications, please see here.
Posted on 04/09/2024
