• Biochemistry
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    Mr Jacob Dundee

    University Position
    PhD student


    My project is to understand the role of microglia in development, tauopathy, and ageing. As a person get older, microglia have been found to ?eat? synapses of stressed but still functional neurons, possibly driving the disease progression of many neurodegenerative disorders. Phagocytic receptors stimulate the ?eating? of nearby synapses as stressed signals are released. These receptors are potential therapeutic targets as a way to halt the progression of symptoms. However, we still know little about the downstream signalling involved with these recepotors. Therefore, my project is to expand on work previously carried out on a specific phagocytic receptor and see the extent of its involvement in development, tauopathy, and ageing in the brain.

    Key Publications

    P2Y6 receptor-dependent microglial phagocytosis of synapses during development regulates synapse density and memory.

    Journal: J Neurosci
    E-pub date: 29 Nov 2023
    Authors: JM Dundee, M Puigdellívol, R Butler, GC Brown

    The microglial P2Y6 receptor mediates neuronal loss and memory deficits in neurodegeneration.

    Journal: Cell Rep
    E-pub date: 28 Dec 2021
    Authors: M Puigdellívol, S Milde, A Vilalta, TOJ Cockram, DH Allendorf, JY Lee, JM Dundee, K Pampuščenko, V Borutaite, HN Nuthall, JH Brelstaff, MG Spillantini, GC Brown


    Activated microglia release β-galactosidase that promotes inflammatory neurodegeneration.

    Journal: Front Aging Neurosci
    E-pub date: 1 Aug 2023
    Authors: EJA Kitchener, JM Dundee, GC Brown

    P2Y6 receptor-dependent microglial phagocytosis of synapses mediates synaptic and memory loss in aging.

    Journal: Aging Cell
    E-pub date: 1 Feb 2023
    Authors: JM Dundee, M Puigdellívol, R Butler, TOJ Cockram, GC Brown

    Inflammatory neuronal loss in the substantia nigra induced by systemic lipopolysaccharide is prevented by knockout of the P2Y6 receptor in mice.

    Journal: J Neuroinflammation
    E-pub date: 11 Oct 2021
    Authors: S Milde, FW van Tartwijk, A Vilalta, TC Hornik, JM Dundee, M Puigdellívol, GC Brown

    The Phagocytic Code Regulating Phagocytosis of Mammalian Cells.

    Journal: Front Immunol
    E-pub date: 1 Aug 2021
    Authors: TOJ Cockram, JM Dundee, AS Popescu, GC Brown