Research Focus


  • Activity-Dependent Myelination
  • Myelin
  • Brain Plasticity
  • Clinical Conditions

  • Multiple sclerosis
  • Depressive disorders
  • Dementia
  • Equipment & Techniques

  • Fluorescence microscopy
  • Microscopy
  • Immunohistochemistry
  • Science Culture

  • Teaching
  • History of Science
  • Back

    Dr Sebastian Timmler

    University Position
    Research Associate


    I study molecular mechanisms of activity-dependent myelination in the central nervous system. I combine the use of primary rat cell culture with optogenetice, light and electron microscopy and proteomics to understand how neuronal activity regulates myelin formation and how myelin influences the function of neuronal circuits.  When I am not in the lab, I enjoys cycling through the English countryside, firing up the barbecue and gardening.

    overlapping myelin sheaths in a mouse with reduced axon-glia interaction

    electron micrograph, mouse optic nerve


    Key Publications


    Periods of synchronized myelin changes shape brain function and plasticity.

    Journal: Nat Neurosci
    E-pub date: 1 Nov 2021
    Authors: O de Faria, H Pivonkova, B Varga, S Timmler, KA Evans, RT Káradóttir