• Psychiatry
  • Back

    Professor Tony Holland

    University Position


    The focus of our interdisciplinary research is on learning disabilities (intellectual disabilities/mental handicap) from different perspectives. Research to date has had the following main themes. First, the relationship between specific genetically determined neurodevelopmental disorders and patterns of development and associated co-morbidities. Research projects have included studies of Prader Willi Syndrome and the associated eating disorder and risks of psychiatric illness; and investigations of the links between Down's syndrome and the high risk for developing Alzheimer's disease. Secondly, studies investigating the interface between people with learning disabilities and the law. This has included research to inform the Mental Capacity Act 2005 and to investigate offending by people with learning disabilies. Thirdly, sociological studies broadly on the theme of 'citizenship' with respect to people with learning disabilities. Since 2008 our group has been part of the NIHR CLAHRC.

    Key Publications


    Isolating residents including wandering residents in care and group homes: Medical ethics and English law in the context of Covid-19.

    Journal: Int J Law Psychiatry
    E-pub date: 1 Aug 2021
    Authors: K Liddell, A Ruck Keene, A Holland, J Huppert, BR Underwood, O Clark, SIG Barclay

    Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman

    Brain-stem serotonin transporter availability in maternal uniparental disomy and deletion Prader-Willi syndrome.

    Journal: Br J Psychiatry
    E-pub date: 1 Jan 2018
    Authors: R Krishnadas, S-A Cooper, A Nicol, S Pimlott, S Soni, AJ Holland, L McArthur, J Cavanagh

    Psychosis in autism: comparison of the features of both conditions in a dually affected cohort.

    Journal: Br J Psychiatry
    E-pub date: 1 Apr 2017
    Authors: FV Larson, AP Wagner, PB Jones, D Tantam, M-C Lai, S Baron-Cohen, AJ Holland

    Testing the ‘Extreme Female Brain’ Theory of Psychosis in Adults with Autism Spectrum Disorder with or without Co-Morbid Psychosis.

    Journal: PLoS One
    E-pub date: 1 Aug 2015
    Authors: FV Larson, M-C Lai, AP Wagner, MRC AIMS Consortium, S Baron-Cohen, AJ Holland

    Recognition of emotion in facial expression by people with Prader-Willi syndrome.

    Journal: J Intellect Disabil Res
    E-pub date: 1 Jan 2011
    Authors: J Whittington, T Holland

    Pre-, peri- and postnatal complications in Prader-Willi syndrome in a UK sample.

    Journal: Early Hum Dev
    E-pub date: 1 May 2008
    Authors: JE Whittington, JV Butler, AJ Holland

    Changing rates of genetic subtypes of Prader-Willi syndrome in the UK.

    Journal: Eur J Hum Genet
    E-pub date: 1 Jan 2007
    Authors: JE Whittington, JV Butler, AJ Holland