Genomic imprinting is an epigenetic mechanism causing genes to be expressed depending on their parental origin. Our research investigates the mechanism and evolution of genomic imprinting and the function of imprinted genes in development and disease. Part of this programme considers the implications of epigenetic control in the development and function of the brain. We also use imprinting as a model system for analysing the epigenetic control of genome function and in particular the roles of DNA methylation and histone modifications in the regulation of gene activity and repression. Our work focuses on an imprinted domain that includes genes and non-coding RNAs that are expressed during neural development and in the adult brain. Little is known about the precise roles of these genes. We are taking molecular approaches using mouse genetic models to address the function of these genes.
