Professor Andrea Brand FRS FMedSci

University Position


Uncovering the molecular mechanisms that control neural stem quiescence and reactivation is crucial for understanding tissue regeneration under normal and pathological conditions and in response to ageing. It is critical to learn not only how stem cell proliferation is induced but also how stem cells can return to a quiescent state, as uncontrolled stem cell division can lead to cancer. My lab combines cutting edge genetic and molecular approaches with advanced imaging to study the reactivation of neural stem cells in vivo. The questions we are addressing are: How do environmental signals influence neural stem cell behaviour? What are these signals and how are they received by the stem cell niche and transmitted to neural stem cells? What are the transcriptional and epigenetic changes in neural stem cells in the transition from quiescence to proliferation? How are neurons maintained in a differentiated state and what molecular changes lead to dedifferentiation and cancer?

Key Publications

Reduced chromatin accessibility correlates with resistance to Notch activation.

Journal: Nature Communications
E-pub date: 25 Apr 2022
Authors: J van den Ameele, R Krautz, SW Cheetham, APA Donovan, O Llorà-Batlle, R Yakob, AH Brand


SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling.

Journal: EMBO J
E-pub date: 2 Nov 2022
Authors: D Sun, O Llora Batlle, J van den Ameele, JC Thomas, P He, K Lim, W Tang, C Xu, KB Meyer, SA Teichmann, JC Marioni, SP Jackson, AH Brand, EL Rawlins

An organoid CRISPRi screen revealed that SOX9 primes human fetal lung tip progenitors to receive WNT and RTK signals

E-pub date: 1 Aug 2022
Authors: D Sun, OL Batlle, J van den Ameele, J Thomas, P He, K Lim, W Tang, C Xu, K Meyer, S Teichmann, J Marioni, S Jackson, A Brand, E Rawlins

In vivo targeted DamID identifies CHD8 genomic targets in fetal mouse brain.

Journal: iScience
E-pub date: 19 Nov 2021
Authors: AA Wade, J van den Ameele, SW Cheetham, R Yakob, AH Brand, AS Nord

Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration.

Journal: Nat Cell Biol
E-pub date: 1 Nov 2019
Authors: L Aloia, MA McKie, G Vernaz, L Cordero-Espinoza, N Aleksieva, J van den Ameele, F Antonica, B Font-Cunill, A Raven, R Aiese Cigliano, G Belenguer, RL Mort, AH Brand, M Zernicka-Goetz, SJ Forbes, EA Miska, M Huch

TaDa! Analysing cell type-specific chromatin in vivo with Targeted DamID.

Journal: Curr Opin Neurobiol
E-pub date: 1 Jun 2019
Authors: J van den Ameele, R Krautz, AH Brand

Targeted DamID reveals differential binding of mammalian pluripotency factors.

Journal: Development
E-pub date: 17 Oct 2018
Authors: SW Cheetham, WH Gruhn, J van den Ameele, R Krautz, TD Southall, T Kobayashi, MA Surani, AH Brand