Research Theme Beyond the Neuron

Andrea Loreto

University Position
Sir Henry Wellcome Postdoctoral Fellow


Axon degeneration is an early feature of several neurodegenerative diseases, including Parkinson's disease, motor neuron disease, multiple sclerosis and glaucoma. I have recently been awarded a Sir Henry Wellcome postdoctoral fellowship to work in Professor Michael Coleman's lab. My primary area of research focuses on understanding the molecular mechanisms leading to axon degeneration after injury and mitochondrial dysfunction. We aim to identify regulators of axon death and eventually study their involvement in the development of neurodegenerative disorders, with a focus on Parkinson's disease.

Key Publications

SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice.

Journal: Front Cell Neurosci
E-pub date: 1 Aug 2023
Authors: SV Fazal, C Mutschler, CZ Chen, M Turmaine, C-Y Chen, Y-P Hsueh, A Ibañez-Grau, A Loreto, A Casillas-Bajo, H Cabedo, RJM Franklin, RA Barker, KR Monk, BJ Steventon, MP Coleman, JA Gomez-Sanchez, P Arthur-Farraj


SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites.

Journal: iScience
E-pub date: 18 Feb 2022
Authors: C Angeletti, A Amici, J Gilley, A Loreto, AG Trapanotto, C Antoniou, E Merlini, MP Coleman, G Orsomando

Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1.

Journal: Elife
E-pub date: 6 Dec 2021
Authors: A Loreto, C Angeletti, W Gu, A Osborne, B Nieuwenhuis, J Gilley, E Merlini, P Arthur-Farraj, A Amici, Z Luo, L Hartley-Tassell, T Ve, LM Desrochers, Q Wang, B Kobe, G Orsomando, MP Coleman

NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo.

Journal: Curr Biol
E-pub date: 20 Mar 2017
Authors: M Di Stefano, A Loreto, G Orsomando, V Mori, F Zamporlini, RP Hulse, J Webster, LF Donaldson, M Gering, N Raffaelli, MP Coleman, J Gilley, L Conforti

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration.

Journal: Cell Death Differ
E-pub date: 1 May 2015
Authors: M Di Stefano, I Nascimento-Ferreira, G Orsomando, V Mori, J Gilley, R Brown, L Janeckova, ME Vargas, LA Worrell, A Loreto, J Tickle, J Patrick, JRM Webster, M Marangoni, FM Carpi, S Pucciarelli, F Rossi, W Meng, A Sagasti, RR Ribchester, G Magni, MP Coleman, L Conforti