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    Professor Albert Cardona

    University Position
    Professor Albert Cardona is pleased to consider applications from prospective PhD students.


    To study the relationship between circuit structure and function, we must know the synaptic connectivity that defines the circuit structure, observe the activity of the neurons in the circuit over time, study how the pattern of activity can change through neuromodulation, and discover the causal relationship between the neurons of the circuit and the behaviours that the circuit governs. And with these data, we can formulate models on the basis of synaptic connectivity that can capture the circuit dynamics, and that can explain how the circuits produce the observed behaviours, and then test these models experimentally. We do all of the above and more in the Drosophila larva, an organism with about 12,000 neurons and an outstanding genetic toolkit for observing and manipulating the activity of its neurons.

    The complete connectome of the Drosophila larval brain

    The connectome of the Drosophila larval brain. The morphologies of all brain neurons, reconstructed from a synapse-resolution EM volume, and the synaptic connectivity matrix of an entire brain. This connectivity information was used to hierarchically cluster all brains into 93 cell types, which were internally consistent based on morphology and known function.

    Key Publications

    Comparative Connectomics Reveals How Partner Identity, Location, and Activity Specify Synaptic Connectivity in Drosophila.

    Journal: Neuron
    E-pub date: 6 Jan 2021
    Authors: J Valdes-Aleman, RD Fetter, EC Sales, EL Heckman, L Venkatasubramanian, CQ Doe, M Landgraf, A Cardona, M Zlatic

    Recurrent architecture for adaptive regulation of learning in the insect brain.

    Journal: Nat Neurosci
    E-pub date: 1 Apr 2020
    Authors: C Eschbach, A Fushiki, M Winding, CM Schneider-Mizell, M Shao, R Arruda, K Eichler, J Valdes-Aleman, T Ohyama, AS Thum, B Gerber, RD Fetter, JW Truman, A Litwin-Kumar, A Cardona, M Zlatic

    The complete connectome of a learning and memory centre in an insect brain.

    Journal: Nature
    E-pub date: 9 Aug 2017
    Authors: K Eichler, F Li, A Litwin-Kumar, Y Park, I Andrade, CM Schneider-Mizell, T Saumweber, A Huser, C Eschbach, B Gerber, RD Fetter, JW Truman, CE Priebe, LF Abbott, AS Thum, M Zlatic, A Cardona

    Competitive Disinhibition Mediates Behavioral Choice and Sequences in Drosophila.

    Journal: Cell
    E-pub date: 20 Oct 2016
    Authors: T Jovanic, CM Schneider-Mizell, M Shao, J-B Masson, G Denisov, RD Fetter, BD Mensh, JW Truman, A Cardona, M Zlatic

    Quantitative neuroanatomy for connectomics in Drosophila.

    Journal: Elife
    E-pub date: 18 Mar 2016
    Authors: CM Schneider-Mizell, S Gerhard, M Longair, T Kazimiers, F Li, MF Zwart, A Champion, FM Midgley, RD Fetter, S Saalfeld, A Cardona

    A multilevel multimodal circuit enhances action selection in Drosophila.

    Journal: Nature
    E-pub date: 30 Apr 2015
    Authors: T Ohyama, CM Schneider-Mizell, RD Fetter, JV Aleman, R Franconville, M Rivera-Alba, BD Mensh, KM Branson, JH Simpson, JW Truman, A Cardona, M Zlatic

    The connectome of an insect brain

    Journal: Science
    Year: 2023
    Authors: Winding M, Pedigo BD, Barnes CL, Patsolic HG, Park Y, Kazimiers T, Fushiki A, Andrade IV, Khandelwal A, Valdes-Aleman J, Li F, Randel N, Barsotti E, Correia A, Fetter RD, Hartenstein V, Priebe C, Vogelstein J, Cardona A, Zlatic M


    Synaptic counts approximate synaptic contact area in Drosophila.

    Journal: PLoS One
    E-pub date: 1 Aug 2022
    Authors: CL Barnes, D Bonnéry, A Cardona

    Neural architectures in the light of comparative connectomics.

    Journal: Curr Opin Neurobiol
    E-pub date: 1 Dec 2021
    Authors: E Barsotti, A Correia, A Cardona

    Circuits for integrating learned and innate valences in the insect brain.

    Journal: Elife
    E-pub date: 10 Nov 2021
    Authors: C Eschbach, A Fushiki, M Winding, B Afonso, IV Andrade, BT Cocanougher, K Eichler, R Gepner, G Si, J Valdes-Aleman, RD Fetter, M Gershow, GS Jefferis, AD Samuel, JW Truman, A Cardona, M Zlatic

    BigStitcher: reconstructing high-resolution image datasets of cleared and expanded samples.

    Journal: Nat Methods
    E-pub date: 1 Sep 2019
    Authors: D Hörl, F Rojas Rusak, F Preusser, P Tillberg, N Randel, RK Chhetri, A Cardona, PJ Keller, H Harz, H Leonhardt, M Treier, S Preibisch

    Conserved neural circuit structure across Drosophila larval development revealed by comparative connectomics.

    Journal: Elife
    E-pub date: 23 Oct 2017
    Authors: S Gerhard, I Andrade, RD Fetter, A Cardona, CM Schneider-Mizell

    Conserved neural circuit structure acrossDrosophilalarval development revealed by comparative connectomics

    E-pub date: 1 Aug 2017
    Authors: S Gerhard, I Andrade, R Fetter, A Cardona, C Schneider-Mizell

    Selective Inhibition Mediates the Sequential Recruitment of Motor Pools.

    Journal: Neuron
    E-pub date: 17 Aug 2016
    Authors: MF Zwart, SR Pulver, JW Truman, A Fushiki, RD Fetter, A Cardona, M Landgraf

    The wiring diagram of a glomerular olfactory system.

    Journal: Elife
    E-pub date: 13 May 2016
    Authors: ME Berck, A Khandelwal, L Claus, L Hernandez-Nunez, G Si, CJ Tabone, F Li, JW Truman, RD Fetter, M Louis, AD Samuel, A Cardona

    A circuit mechanism for the propagation of waves of muscle contraction in Drosophila.

    Journal: Elife
    E-pub date: 15 Feb 2016
    Authors: A Fushiki, MF Zwart, H Kohsaka, RD Fetter, A Cardona, A Nose

    Fiji: an open-source platform for biological-image analysis.

    Journal: Nat Methods
    E-pub date: 28 Jun 2012
    Authors: J Schindelin, I Arganda-Carreras, E Frise, V Kaynig, M Longair, T Pietzsch, S Preibisch, C Rueden, S Saalfeld, B Schmid, J-Y Tinevez, DJ White, V Hartenstein, K Eliceiri, P Tomancak, A Cardona

    Elastic volume reconstruction from series of ultra-thin microscopy sections.

    Journal: Nat Methods
    E-pub date: 10 Jun 2012
    Authors: S Saalfeld, R Fetter, A Cardona, P Tomancak

    CATMAID: collaborative annotation toolkit for massive amounts of image data.

    Journal: Bioinformatics
    E-pub date: 1 Aug 2009
    Authors: S Saalfeld, A Cardona, V Hartenstein, P Tomancak