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Dr Alvaro Sanchez-Martinez

University Position
Research Associate

Interests

My general research interests are focused on mitochondrial related early-onset and ageing diseases. In particular, how mitochondrial damage/dysfunction and environmental factors, such as stress, may influence ageing and onset as well as progression of these diseases. These interests have lead me to examine the mitochondrial quality control mechanisms, and also how adjusting the organismal/cellular environment, in relation to external/internal stress, may ameliorate the affects of disease and lead to targets for treatment through genetic approaches.

Key Publications

Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models

DOI: http://doi.org/10.1186/s13024-024-00701-3
Journal: Mol Neurodegener
E-pub date: 25 Jan 2024
Authors: A Martinez, A Sanchez-Martinez, JT Pickering, MJ Twyning, A Terriente-Felix, P-L Chen, C-H Chen, AJ Whitworth

Parkin drives pS65-Ub turnover independently of canonical autophagy in Drosophila.

DOI: http://doi.org/10.15252/embr.202153552
Journal: EMBO Rep
E-pub date: 6 Dec 2022
Authors: JL Usher, A Sanchez-Martinez, A Terriente-Felix, P-L Chen, JJ Lee, C-H Chen, AJ Whitworth

Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo.

DOI: http://doi.org/10.1016/j.celrep.2019.04.033
Journal: Cell Rep
E-pub date: 30 Apr 2019
Authors: R Tufi, TP Gleeson, S von Stockum, VL Hewitt, JJ Lee, A Terriente-Felix, A Sanchez-Martinez, E Ziviani, AJ Whitworth

Publications

Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes inC9orf72ALS/FTD models

DOI: http://doi.org/10.26508/lsa.202402853
Journal: Life Sci Alliance
E-pub date: 1 Sep 2024
Authors: WH Au, L Miller-Fleming, A Sanchez-Martinez, JAK Lee, MJ Twyning, HA Prag, L Raik, SP Allen, PJ Shaw, L Ferraiuolo, H Mortiboys, AJ Whitworth

Analysis of Mitophagy Reporters in Drosophila.

DOI: http://doi.org/10.1007/978-1-0716-4067-8_7
Journal: Methods Mol Biol
E-pub date: 1 Aug 2024
Authors: A Sanchez-Martinez, A Martinez, AJ Whitworth

Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction in C9orf72 ALS/FTD in vivo models and patient iNeurons

DOI: http://doi.org/10.1101/2023.10.02.560439
Journal:
E-pub date: 1 Aug 2023
Authors: WH Au, L Miller-Fleming, A Sanchez-Martinez, J Lee, M Twyning, H Prag, S Granger, K Roome, L Ferraiuolo, H Mortiboys, A Whitworth

A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins.

DOI: http://doi.org/10.1126/scitranslmed.abo3823
Journal: Sci Transl Med
E-pub date: 1 Mar 2023
Authors: LM Castelli, Y-H Lin, A Sanchez-Martinez, A Gül, K Mohd Imran, A Higginbottom, SK Upadhyay, NM Márkus, R Rua Martins, J Cooper-Knock, C Montmasson, R Cohen, A Walton, CS Bauer, KJ De Vos, RJ Mead, M Azzouz, C Dominguez, L Ferraiuolo, PJ Shaw, AJ Whitworth, GM Hautbergue