My general research interests are focused on mitochondrial related early-onset and ageing diseases. In particular, how mitochondrial damage/dysfunction and environmental factors, such as stress, may influence ageing and onset as well as progression of these diseases. These interests have lead me to examine the mitochondrial quality control mechanisms, and also how adjusting the organismal/cellular environment, in relation to external/internal stress, may ameliorate the affects of disease and lead to targets for treatment through genetic approaches.