Dr Alvaro Sanchez-Martinez

University Position
Research Associate


My general research interests are focused on mitochondrial related early-onset and ageing diseases. In particular, how mitochondrial damage/dysfunction and environmental factors, such as stress, may influence ageing and onset as well as progression of these diseases. These interests have lead me to examine the mitochondrial quality control mechanisms, and also how adjusting the organismal/cellular environment, in relation to external/internal stress, may ameliorate the affects of disease and lead to targets for treatment through genetic approaches.

Key Publications

A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins.

Journal: Sci Transl Med
E-pub date: 1 Mar 2023
Authors: LM Castelli, Y-H Lin, A Sanchez-Martinez, A Gül, K Mohd Imran, A Higginbottom, SK Upadhyay, NM Márkus, R Rua Martins, J Cooper-Knock, C Montmasson, R Cohen, A Walton, CS Bauer, KJ De Vos, RJ Mead, M Azzouz, C Dominguez, L Ferraiuolo, PJ Shaw, AJ Whitworth, GM Hautbergue

Parkin drives pS65-Ub turnover independently of canonical autophagy in Drosophila.

Journal: EMBO Rep
E-pub date: 6 Dec 2022
Authors: JL Usher, A Sanchez-Martinez, A Terriente-Felix, P-L Chen, JJ Lee, C-H Chen, AJ Whitworth

Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo.

Journal: Cell Rep
E-pub date: 30 Apr 2019
Authors: R Tufi, TP Gleeson, S von Stockum, VL Hewitt, JJ Lee, A Terriente-Felix, A Sanchez-Martinez, E Ziviani, AJ Whitworth


Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes inPink1/parkinmodels

E-pub date: 1 Aug 2023
Authors: A Martinez, A Sanchez-Martinez, J Pickering, M Twyning, A Terriente-Felix, P-L Chen, C-H Chen, A Whitworth

Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction in C9orf72 ALS/FTD in vivo models and patient iNeurons

E-pub date: 1 Aug 2023
Authors: WH Au, L Miller-Fleming, A Sanchez-Martinez, J Lee, M Twyning, H Prag, S Granger, K Roome, L Ferraiuolo, H Mortiboys, A Whitworth