Menu

EMAIL apatton@mrc-lmb.cam.ac.uk
Institute
  • MRC Laboratory of Molecular Biology
    • ORCID iDClick to view ORCID profile
    Research Theme Neurons, Circuits and Networks Beyond the Neuron
    Research Focus

    Keywords

  • Circadian Rhythms
  • Brain Network
  • Neurons
  • Astrocytes
  • GABA
  • Neuropeptides
  • Patch-Clamp Electrophysiology
  • Transcriptomics
  • Calcium Imaging
  • Bioluminescence Imaging
  • Live Imaging

    • Clinical Conditions

  • Sleep disorders

    • Equipment & Techniques

  • Electrophysiological recording techniques
  • Calcium imaging
  • Microscopy
  • Fluorescence microscopy
  • Confocal microscopy
  • Whole cell patch clamp

    • Back

    Dr Andrew Patton

    University Position
    Research Associate
    Senior Investigator Scientist

    Interests

    Study of circadian rhythms in the mammalian suprachiasmatic nucleus (SCN) using genetic, imaging, transcriptomic and electrophysiological approaches. My primary research focuses on the role of GABAergic and neuropeptidergic signalling within the SCN and how astrocytes and neurons contribute to the network-wide coherence of circadian rhythmicity. Additional projects include the manipulation of organotypic SCN slices using pharmacology and optogenetic approaches.

    Key Publications

    The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian circuit

    DOI: https://doi.org/10.1038/s41467-020-17110-x
    Journal: Nature Communications
    Year: 2020
    Authors: Patton, AP; Edwards, MD; Smyllie, NJ; Hamnett, R; Chesham, JE; Brancaccio, M; Maywood, ES; Hastings, MH

    Astrocytes Sustain Circadian Oscillation and Bidirectionally Determine Circadian Period, But Do Not Regulate Circadian Phase in the Suprachiasmatic Nucleus

    DOI: https://doi.org/10.1523/JNEUROSCI.2337-21.2022
    Journal: Journal of Neuroscience
    Year: 2022
    Authors: Patton, AP; Smyllie, NJ; Chesham, JE; Hastings, MH

    Astrocytic control of extracellular GABA drives circadian timekeeping in the suprachiasmatic nucleus

    DOI: https://doi.org/10.1073/pnas.2301330120
    Journal: PNAS
    Year: 2023
    Authors: Patton, AP; Morris, EL; McManus, D; Wang, H; Li, Y; Chin, JW; Hastings, MH

    Neuron-Astrocyte Interactions and Circadian Timekeeping in Mammals

    DOI: https://doi.org/10.1177/10738584241245307
    Journal: The Neuroscientist
    Year: 2025
    Authors: Smyllie, NJ; Hastings, MH; Patton, AP

    Publications

    PICK1 inhibition of the Arp2/3 complex controls dendritic spine size and synaptic plasticity.

    DOI: https://doi.org/10.1038/emboj.2010.357
    Journal: EMBO J
    Year: 2011
    Authors: Nakamura, Y; Wood, CL; Patton, AP; Jaafari, N; Henley, JM; Mellor, JR; Hanley, JG

    Combined Pharmacological and Genetic Manipulations Unlock Unprecedented Temporal Elasticity and Reveal Phase-Specific Modulation of the Molecular Circadian Clock of the Mouse Suprachiasmatic Nucleus

    DOI: https://doi.org/10.1523/JNEUROSCI.0958-16.2016
    Journal: Journal of Neuroscience
    Year: 2016
    Authors: Patton, AP; Chesham, JE; Hastings, MH

    Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.

    DOI: https://doi.org/10.1016/j.neuron.2017.02.030
    Journal: Neuron
    Year: 2017
    Authors: Brancaccio, M; Patton, AP; Chesham, JE; Maywood, ES; Hastings, MH

    The suprachiasmatic nucleus.

    DOI: https://10.1016/j.cub.2018.06.052
    Journal: Current Biology
    Year: 2018
    Authors: Patton, AP; Hastings, MH

    Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrhythmic Cry-deficient mice

    DOI: https://doi.org/10.1073/pnas.1811438115
    Journal: PNAS
    Year: 2018
    Authors: Maywood, ES; Elliott, TS; Patton, AP; Krogager, TP; Chesham, JE; Ernst, RJ; Beránek, V; Brancaccio, M; Chin, JW; Hastings, MH

    Cell-autonomous clock of astrocytes drives circadian behavior in mammals

    DOI: https://doi.org/10.1126/science.aat4104
    Journal: Science
    Year: 2019
    Authors: Brancaccio, M; Edwards, MD; Patton, AP; Smyllie, NJ; Chesham, JE; Maywood, ES; Hastings, MH

    Molecular-genetic Manipulation of the Suprachiasmatic Nucleus Circadian Clock

    DOI: https://doi.org/10.1016/J.JMB.2020.01.019
    Journal: Journal of Molecular Biology
    Year: 2020
    Authors: Hastings, MH; Smyllie, NJ; Patton, AP

    Single‐cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin‐driven circadian network

    DOI: https://doi.org/10.15252/embj.2021108614
    Journal: EMBO J
    Year: 2021
    Authors: Morris, EL; Patton, AP; Chesham, JE; Crisp, A; Adamson, A; Hastings, MH

    Cryptochrome 1 as a state variable of the circadian clockwork of the suprachiasmatic nucleus: Evidence from translational switching

    DOI: https://doi.org/10.1073/pnas.2203563119
    Journal: PNAS
    Year: 2022
    Authors: McManus, D; Polidarova, L; Smyllie, NJ; Patton, AP; Chesham, JE; Maywood, ES; Chin, JW; Hastings, MH

    The Mammalian Circadian Time-Keeping System

    DOI: https://doi.org/10.3233/jhd-230571
    Journal: Journal of Huntington's Disease
    Year: 2023
    Authors: Patton, AP; Hastings, MH

    Cells and Circuits of the Suprachiasmatic Nucleus and the Control of Circadian Behaviour and Sleep

    DOI: https://doi.org/10.1007/978-3-031-22468-3_2
    Journal: Healthy Ageing and Longevity
    Year: 2023
    Authors: Patton, AP; Hastings, MH; Smyllie, NJ

    Molecular genetic analysis of the role of Cryptochromes in the circadian clock of the suprachiasmatic nucleus

    DOI:
    Journal: Circadian Clocks: Proceedings of the Sapporo Symposium on Biological Rhythm
    Year: 2024
    Authors: Smyllie, NJ; Campbell, A; McManus, D; Patton, AP; Hastings, MH

    PERfect Day: reversible and dose‐dependent control of circadian time‐keeping in the mouse suprachiasmatic nucleus by translational switching of PERIOD2 protein expression

    DOI: https://doi.org/10.1111/ejn.16537
    Journal: European Journal of Neuroscience
    Year: 2024
    Authors: McManus, D; Patton, AP; Smyllie, NJ; Chin, JW; Hastings, MH