Research Theme Beyond the Neuron

Dr Tony Coll

University Position
Associate Professor


My current research continues to focus upon the roles of the hypothalamus in the control of energy balance. Our current understanding of the central control of appetite has relied heavily upon mouse models and I continue to utilise the power of both murine genetics and whole animal physiological studies to address these issues. I aim to model disease-related mutations in murine systems and continue the powerful, synergistic relationship between human genetics and murine modelling which has been so fruitful in understanding complex systems biology.

Key Publications

A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing.

Journal: Mol Metab
E-pub date: 1 Nov 2021
Authors: GKC Dowsett, BYH Lam, JA Tadross, I Cimino, D Rimmington, AP Coll, J Polex-Wolf, LB Knudsen, C Pyke, GSH Yeo

MC3R links nutritional state to childhood growth and the timing of puberty.

Journal: Nature
E-pub date: 1 Nov 2021
Authors: BYH Lam, A Williamson, S Finer, FR Day, JA Tadross, A Gonçalves Soares, K Wade, P Sweeney, MN Bedenbaugh, DT Porter, A Melvin, KLJ Ellacott, RN Lippert, S Buller, J Rosmaninho-Salgado, GKC Dowsett, KE Ridley, Z Xu, I Cimino, D Rimmington, K Rainbow, K Duckett, S Holmqvist, A Khan, X Dai, EG Bochukova, Genes & Health Research Team, RC Trembath, HC Martin, AP Coll, DH Rowitch, NJ Wareham, DA van Heel, N Timpson, RB Simerly, KK Ong, RD Cone, C Langenberg, JRB Perry, GS Yeo, S O'Rahilly


Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome.

Journal: J Clin Invest
E-pub date: 1 Mar 2018
Authors: J Polex-Wolf, BY Lam, R Larder, J Tadross, D Rimmington, F Bosch, VJ Cenzano, E Ayuso, MK Ma, K Rainbow, AP Coll, S O'Rahilly, GS Yeo

Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity.

Journal: Cell
E-pub date: 28 Jan 2016
Authors: K Dalgaard, K Landgraf, S Heyne, A Lempradl, J Longinotto, K Gossens, M Ruf, M Orthofer, R Strogantsev, M Selvaraj, TT-H Lu, E Casas, R Teperino, MA Surani, I Zvetkova, D Rimmington, YCL Tung, B Lam, R Larder, GSH Yeo, S O'Rahilly, T Vavouri, E Whitelaw, JM Penninger, T Jenuwein, C-L Cheung, AC Ferguson-Smith, AP Coll, A Körner, JA Pospisilik