Professor Anthony Davenport

University Position

Professor

Interests

Our research group focuses on understanding the role of G-protein-coupled receptors (GPCRs, targets for about ~50% of current drugs) together with their transmitters in humans. We use in vitro pharmacology, to determine how these are altered with disease. Major interests include the role of apelin, Elabela and endothelin-1 in human pathophysiology. Previous research has focussed on other peptides including urotensin II, ghrelin, neuromedin U, kisspeptins, trace amines.Wider research interests are reflected through co-executive member of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification. This committee has oversight of medicines and tool compounds databases: GuidetoPharmacology https://www.guidetopharmacology.org/ GuidetoImmunoPharmacology https://www.guidetoimmunopharmacology.org/immuno/index.jsp GuidetoPharmacologyOfMalaria https://www.guidetopharmacology.org/malaria/gtmpHelpPage.jsp

Key Publications

Imaging atherosclerotic plaque inflammation with [18F]- fluorodeoxyglucose positron emission tomography

DOI: http://doi.org/10.17863/CAM.16643
Journal:
E-pub date: 1 Jan 2003
Authors: J Rudd

Publications

Somatostatin Receptor PET/MR Imaging of Inflammation in Patients With Large Vessel Vasculitis and Atherosclerosis.

DOI: http://doi.org/10.1016/j.jacc.2022.10.034
Journal: J Am Coll Cardiol
E-pub date: 31 Jan 2023
Authors: A Ćorović, C Wall, M Nus, D Gopalan, Y Huang, M Imaz, M Zulcinski, M Peverelli, A Uryga, J Lambert, D Bressan, RT Maughan, C Pericleous, S Dubash, N Jordan, DR Jayne, SP Hoole, PA Calvert, AF Dean, D Rassl, T Barwick, M Iles, M Frontini, G Hannon, R Manavaki, TD Fryer, L Aloj, MJ Graves, FJ Gilbert, MR Dweck, DE Newby, ZA Fayad, G Reynolds, AW Morgan, EO Aboagye, AP Davenport, HF Jørgensen, Z Mallat, MR Bennett, JE Peters, JHF Rudd, JC Mason, JM Tarkin

Vascular Imaging With 18F-Fluorodeoxyglucose Positron Emission Tomography Is Influenced by Hypoxia.

DOI: http://doi.org/10.1016/j.jacc.2017.01.050
Journal: J Am Coll Cardiol
E-pub date: 11 Apr 2017
Authors: FR Joshi, R Manavaki, TD Fryer, NL Figg, JC Sluimer, FI Aigbirhio, AP Davenport, PJ Kirkpatrick, EA Warburton, JHF Rudd

Detection of Atherosclerotic Inflammation by 68Ga-DOTATATE PET Compared to [18F]FDG PET Imaging.

DOI: http://doi.org/10.1016/j.jacc.2017.01.060
Journal: J Am Coll Cardiol
E-pub date: 11 Apr 2017
Authors: JM Tarkin, FR Joshi, NR Evans, MM Chowdhury, NL Figg, AV Shah, LT Starks, A Martin-Garrido, R Manavaki, E Yu, RE Kuc, L Grassi, R Kreuzhuber, MA Kostadima, M Frontini, PJ Kirkpatrick, PA Coughlin, D Gopalan, TD Fryer, JR Buscombe, AM Groves, WH Ouwehand, MR Bennett, EA Warburton, AP Davenport, JHF Rudd

Dynamic in vivo imaging of receptors in small animals using positron emission tomography

DOI: http://doi.org/10.1007/978-1-61779-909-9-11
Journal: Methods in Molecular Biology
E-pub date: 1 Aug 2012
Authors: P Johnström, TD Fryer, JL Bird, HK Richards, AP Davenport

Dynamic in vivo imaging of receptors in small animals using positron emission tomography.

DOI: http://doi.org/10.1007/978-1-61779-909-9_11
Journal: Methods Mol Biol
E-pub date: 1 Aug 2012
Authors: P Johnström, TD Fryer, JL Bird, HK Richards, AP Davenport

Positron emission tomography of [18F]-big endothelin-1 reveals renal excretion but tissue-specific conversion to [18F]-endothelin-1 in lung and liver.

DOI: http://doi.org/10.1111/j.1476-5381.2010.00641.x
Journal: Br J Pharmacol
E-pub date: 1 Feb 2010
Authors: P Johnström, TD Fryer, HK Richards, JJ Maguire, JC Clark, JD Pickard, AP Davenport

FDG-PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis.

DOI: http://doi.org/10.1007/s10554-009-9506-6
Journal: Int J Cardiovasc Imaging
E-pub date: 1 Jan 2010
Authors: JR Davies, D Izquierdo-Garcia, JHF Rudd, N Figg, HK Richards, JLE Bird, FI Aigbirhio, AP Davenport, PL Weissberg, TD Fryer, EA Warburton

Strategy for improved [(11)C]DAA1106 radiosynthesis and in vivo peripheral benzodiazepine receptor imaging using microPET, evaluation of [(11)C]DAA1106.

DOI: http://doi.org/10.1016/j.nucmedbio.2007.02.009
Journal: Nucl Med Biol
E-pub date: 1 May 2007
Authors: KC Probst, D Izquierdo, JLE Bird, L Brichard, D Franck, JR Davies, TD Fryer, HK Richards, JC Clark, AP Davenport, PL Weissberg, EA Warburton

Dynamic in vivo imaging of receptors in small animals using positron emission tomography.

DOI: http://doi.org/10.1385/1-59259-927-3:217
Journal:
E-pub date: 1 Aug 2005
Authors: P Johnström, TD Fryer, HK Richards, O Barret, AP Davenport

Positron emission tomography using 18F-labelled endothelin-1 reveals prevention of binding to cardiac receptors owing to tissue-specific clearance by ET B receptors in vivo.

DOI: http://doi.org/10.1038/sj.bjp.0706064
Journal: Br J Pharmacol
E-pub date: 1 Jan 2005
Authors: P Johnström, TD Fryer, HK Richards, NG Harris, O Barret, JC Clark, JD Pickard, AP Davenport

In vivo imaging of cardiovascular endothelin receptors using the novel radiolabelled antagonist [18F]-SB209670 and positron emission tomography (microPET).

DOI: http://doi.org/10.1097/01.fjc.0000166217.27544.6b
Journal: J Cardiovasc Pharmacol
E-pub date: 1 Nov 2004
Authors: P Johnström, TD Fryer, HK Richards, O Barret, JC Clark, EH Ohlstein, JD Pickard, AP Davenport

(18)F-Endothelin-1, a positron emission tomography (PET) radioligand for the endothelin receptor system: radiosynthesis and in vivo imaging using microPET.

DOI: http://doi.org/10.1042/CS103S004S
Journal: Clin Sci (Lond)
E-pub date: 31 Aug 2002
Authors: P Johnström, NG Harris, TD Fryer, O Barret, JC Clark, JD Pickard, AP Davenport

Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography.

DOI: http://doi.org/10.1161/01.cir.0000020548.60110.76
Journal: Circulation
E-pub date: 11 Jun 2002
Authors: JHF Rudd, EA Warburton, TD Fryer, HA Jones, JC Clark, N Antoun, P Johnström, AP Davenport, PJ Kirkpatrick, BN Arch, JD Pickard, PL Weissberg