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Research Focus

Keywords

  • Working Memory
  • Executive Function
  • Attention
  • Inhibition
  • Cognitive Function
  • Cognitive Psychopharmacology
  • Clinical Conditions

  • Traumatic brain injury
  • Cognitive impairment
  • Depressive disorders
  • Attention deficit hyperactivity disorder
  • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Behavioural analysis
  • Statistical analysis
  • Computational modelling
  • Neuropsychological testing
  • Randomised control trials
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    Mr Alexander Peattie

    University Position
    PhD student

    Interests

    My work has focussed on the neurocognitive sequalae of chronic Traumatic Brain Injury (TBI), particularly the domains of response inhibition, working memory, executive function, and sustained attention – and how the pharmacological catecholaminergic stimulant Methylphenidate (MPh) ameliorates cognitive deficits by upregulating synaptic DA/NA concentrations. This research has used both inside-scanner and outside-scanner neuropsychological testing via the CANTAB cognitive assessments. This work has also investigated their cognitive ability and psychiatric status using the NART, MMSE, NPI, BDI, VAS, and SF-36 questionnaires among others. I utilised both task-based and resting-state fMRI as well as DTI approaches to characterise the neurobiological underpinnings of TBI-deficits and MPh’s treatment effects compared to normative healthy control data. I have also collaborated with others in analysing patients with Disorders of Consciousness (DOC), the neurofunctional correlates of anaesthesia, and the effects of psychopharmacological modulators on resting-state fMRI data. TBI, DOC, and depressive conditions share neurological, behavioural, and cognitive deficits due to damage to monoaminergic structures http://anaesthetics.medschl.cam.ac.uk/staff/alex-peattie/

    Key Publications

    Publications