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Research Focus

Keywords

  • Genes
  • Neurodevelopment & Cognition
  • GWAS
  • Clinical Conditions

  • Anxiety disorders
  • Attention deficit hyperactivity disorder
  • Autism
  • Autism spectrum condition
  • Depressive disorders
  • Genetic disorders
  • Learning disabilities
  • Post-traumatic stress disorder
  • Stress
  • Equipment & Techniques

  • Behavioural analysis
  • Cross-sectional and cohort studies
  • Science Culture

  • Reproducibility in Science
  • Open Access
  • Open-Source Science
  • Teaching
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    Dr Andrea Mariana Santangelo PhD

    (she/her/hers)
    University Position
    Research Associate

    Interests

    I am a molecular biologist, with expertise in genetics and neuroscience. My research focuses on understanding the genetics and molecular mechanisms underlying psychiatric and neurodevelopmental disorders at all levels, from genes to behaviour. I take an overarching approach that brings together animal and human research on the basis of genetic analysis. I have worked with both rodents and non-human primates, and more recently with human data, studying the associations between genetic variation and psychiatric traits. Given the shared genetic liability across psychiatric disorders, I use a transdiagnostic approach by looking at psychiatric dimensions, such as social, emotional and cognitive abilities, rather than diagnoses.

    Key Publications

    Chemogenetics identifies separate area 25 brain circuits involved in anhedonia and anxiety in marmosets.

    DOI: http://doi.org/10.1126/scitranslmed.ade1779
    Journal: Sci Transl Med
    E-pub date: 5 Apr 2023
    Authors: CM Wood, L Alexander, J Alsiö, AM Santangelo, L McIver, GJ Cockcroft, AC Roberts

    Glutamate Within the Marmoset Anterior Hippocampus Interacts with Area 25 to Regulate the Behavioral and Cardiovascular Correlates of High-Trait Anxiety.

    DOI: http://doi.org/10.1523/JNEUROSCI.2451-18.2018
    Journal: J Neurosci
    E-pub date: 17 Apr 2019
    Authors: JL Zeredo, SKL Quah, CU Wallis, L Alexander, GJ Cockcroft, AM Santangelo, J Xia, Y Shiba, JW Dalley, RN Cardinal, AC Roberts, HF Clarke

    Publications

    Differential Contribution of Anterior and Posterior Midcingulate Subregions to Distal and Proximal Threat Reactivity in Marmosets.

    DOI: http://doi.org/10.1093/cercor/bhab121
    Journal: Cereb Cortex
    E-pub date: 26 Aug 2021
    Authors: SS Rahman, K Mulvihill, CM Wood, SKL Quah, NK Horst, HF Clarke, GJ Cockcroft, AM Santangelo, AC Roberts

    Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.

    DOI: http://doi.org/10.1073/pnas.1902087116
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 16 Jul 2019
    Authors: AM Santangelo, SJ Sawiak, T Fryer, Y Hong, Y Shiba, HF Clarke, PJ Riss, V Ferrari, R Tait, J Suckling, FI Aigbirhio, AC Roberts

    Converging Prefronto-Insula-Amygdala Pathways in Negative Emotion Regulation in Marmoset Monkeys.

    DOI: http://doi.org/10.1016/j.biopsych.2017.06.016
    Journal: Biol Psychiatry
    E-pub date: 15 Dec 2017
    Authors: Y Shiba, L Oikonomidis, S Sawiak, TD Fryer, YT Hong, G Cockcroft, AM Santangelo, AC Roberts

    Novel Primate Model of Serotonin Transporter Genetic Polymorphisms Associated with Gene Expression, Anxiety and Sensitivity to Antidepressants.

    DOI: http://doi.org/10.1038/npp.2016.41
    Journal: Neuropsychopharmacology
    E-pub date: 31 Aug 2016
    Authors: AM Santangelo, M Ito, Y Shiba, HF Clarke, EH Schut, G Cockcroft, AC Ferguson-Smith, AC Roberts

    Novel Primate Model of Serotonin Transporter Genetic Polymorphisms Associated with Gene Expression, Anxiety and Sensitivity to Antidepressants

    DOI: http://doi.org/10.1038/npp.2016.41;
    Journal: Neuropsychopharmacology
    E-pub date: 21 Mar 2016
    Authors: AM Santangelo, M Ito, Y Shiba, HF Clarke, EHS Schut, G Cockcroft, AC Ferguson-Smith, AC Roberts

    Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion.

    DOI: http://doi.org/10.1016/j.biopsych.2012.03.007
    Journal: Biological Psychiatry
    E-pub date: 15 Aug 2012
    Authors: C Agustín-Pavón, K Braesicke, Y Shiba, AM Santangelo, Y Mikheenko, G Cockroft, F Asma, H Clarke, M-S Man, AC Roberts