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    Research Theme The Social Brain Lifelong Brain Development and Brain Ageing
    Research Focus

    Keywords

  • Genes
  • Neurodevelopment & Cognition
  • GWAS

    • Clinical Conditions

  • Anxiety disorders
  • Attention deficit hyperactivity disorder
  • Autism
  • Autism spectrum condition
  • Depressive disorders
  • Genetic disorders
  • Learning disabilities
  • Post-traumatic stress disorder
  • Stress

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  • Behavioural analysis
  • Cross-sectional and cohort studies

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  • Reproducibility in Science
  • Open Access
  • Open-Source Science
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    Dr Andrea Mariana Santangelo PhD

    (she/her/hers)
    University Position
    Research Associate

    Interests

    I am a molecular biologist, with expertise in genetics and neuroscience. My research focuses on understanding the genetics and molecular mechanisms underlying psychiatric and neurodevelopmental disorders at all levels, from genes to behaviour. I take an overarching approach that brings together animal and human research on the basis of genetic analysis. I have worked with both rodents and non-human primates, and more recently with human data, studying the associations between genetic variation and psychiatric traits. Given the shared genetic liability across psychiatric disorders, I use a transdiagnostic approach by looking at psychiatric dimensions, such as social, emotional and cognitive abilities, rather than diagnoses.

    Collaborators

    Cambridge
  • Kate Baker
  • Nicholas Mundy
    • External
  • Nicholas Timpson
  • Marilia Barros
  • Jorge Zeredo
  • Eduardo Gascon
  • Elsa Addessi

    • Key Publications

    Chemogenetics identifies separate area 25 brain circuits involved in anhedonia and anxiety in marmosets.

    DOI: http://doi.org/10.1126/scitranslmed.ade1779
    Journal: Sci Transl Med
    E-pub date: 5 Apr 2023
    Authors: CM Wood, L Alexander, J Alsiö, AM Santangelo, L McIver, GJ Cockcroft, AC Roberts

    Glutamate Within the Marmoset Anterior Hippocampus Interacts with Area 25 to Regulate the Behavioral and Cardiovascular Correlates of High-Trait Anxiety.

    DOI: http://doi.org/10.1523/JNEUROSCI.2451-18.2018
    Journal: J Neurosci
    E-pub date: 17 Apr 2019
    Authors: JL Zeredo, SKL Quah, CU Wallis, L Alexander, GJ Cockcroft, AM Santangelo, J Xia, Y Shiba, JW Dalley, RN Cardinal, AC Roberts, HF Clarke

    Publications

    Differential Contribution of Anterior and Posterior Midcingulate Subregions to Distal and Proximal Threat Reactivity in Marmosets.

    DOI: http://doi.org/10.1093/cercor/bhab121
    Journal: Cereb Cortex
    E-pub date: 26 Aug 2021
    Authors: SS Rahman, K Mulvihill, CM Wood, SKL Quah, NK Horst, HF Clarke, GJ Cockcroft, AM Santangelo, AC Roberts

    Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.

    DOI: http://doi.org/10.1073/pnas.1902087116
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 16 Jul 2019
    Authors: AM Santangelo, SJ Sawiak, T Fryer, Y Hong, Y Shiba, HF Clarke, PJ Riss, V Ferrari, R Tait, J Suckling, FI Aigbirhio, AC Roberts

    Converging Prefronto-Insula-Amygdala Pathways in Negative Emotion Regulation in Marmoset Monkeys.

    DOI: http://doi.org/10.1016/j.biopsych.2017.06.016
    Journal: Biol Psychiatry
    E-pub date: 15 Dec 2017
    Authors: Y Shiba, L Oikonomidis, S Sawiak, TD Fryer, YT Hong, G Cockcroft, AM Santangelo, AC Roberts

    Novel Primate Model of Serotonin Transporter Genetic Polymorphisms Associated with Gene Expression, Anxiety and Sensitivity to Antidepressants.

    DOI: http://doi.org/10.1038/npp.2016.41
    Journal: Neuropsychopharmacology
    E-pub date: 31 Aug 2016
    Authors: AM Santangelo, M Ito, Y Shiba, HF Clarke, EH Schut, G Cockcroft, AC Ferguson-Smith, AC Roberts

    Novel Primate Model of Serotonin Transporter Genetic Polymorphisms Associated with Gene Expression, Anxiety and Sensitivity to Antidepressants

    DOI: http://doi.org/10.1038/npp.2016.41;
    Journal: Neuropsychopharmacology
    E-pub date: 21 Mar 2016
    Authors: AM Santangelo, M Ito, Y Shiba, HF Clarke, EHS Schut, G Cockcroft, AC Ferguson-Smith, AC Roberts

    Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion.

    DOI: http://doi.org/10.1016/j.biopsych.2012.03.007
    Journal: Biological Psychiatry
    E-pub date: 15 Aug 2012
    Authors: C Agustín-Pavón, K Braesicke, Y Shiba, AM Santangelo, Y Mikheenko, G Cockroft, F Asma, H Clarke, M-S Man, AC Roberts