Dr Andrea Santangelo M

University Position

Research Associate

Interests

My work focuses on gene variation associated to emotional and cognitive behaviour. In particular, I study polymorphisms in the serotonin transporter gene that are linked to vulnerability to early-life stress and the development of affective disorders. Our research includes behavioural testing, brain imaging and molecular studies to understand the neurodevelopmental changes and molecular mechanisms that underlie the individual differences in affective behaviour. I am available as a consultant.

Key Publications

Chemogenetics identifies separate area 25 brain circuits involved in anhedonia and anxiety in marmosets.

DOI: http://doi.org/10.1126/scitranslmed.ade1779
Journal: Sci Transl Med
E-pub date: 5 Apr 2023
Authors: CM Wood, L Alexander, J Alsiö, AM Santangelo, L McIver, GJ Cockcroft, AC Roberts

Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.

DOI: http://doi.org/10.1073/pnas.1902087116
Journal: Proc Natl Acad Sci U S A
E-pub date: 16 Jul 2019
Authors: AM Santangelo, SJ Sawiak, T Fryer, Y Hong, Y Shiba, HF Clarke, PJ Riss, V Ferrari, R Tait, J Suckling, FI Aigbirhio, AC Roberts

Glutamate Within the Marmoset Anterior Hippocampus Interacts with Area 25 to Regulate the Behavioral and Cardiovascular Correlates of High-Trait Anxiety.

DOI: http://doi.org/10.1523/JNEUROSCI.2451-18.2018
Journal: J Neurosci
E-pub date: 17 Apr 2019
Authors: JL Zeredo, SKL Quah, CU Wallis, L Alexander, GJ Cockcroft, AM Santangelo, J Xia, Y Shiba, JW Dalley, RN Cardinal, AC Roberts, HF Clarke

Publications

Differential Contribution of Anterior and Posterior Midcingulate Subregions to Distal and Proximal Threat Reactivity in Marmosets.

DOI: http://doi.org/10.1093/cercor/bhab121
Journal: Cereb Cortex
E-pub date: 26 Aug 2021
Authors: SS Rahman, K Mulvihill, CM Wood, SKL Quah, NK Horst, HF Clarke, GJ Cockcroft, AM Santangelo, AC Roberts

Novel Primate Model of Serotonin Transporter Genetic Polymorphisms Associated with Gene Expression, Anxiety and Sensitivity to Antidepressants.

DOI: http://doi.org/10.1038/npp.2016.41
Journal: Neuropsychopharmacology
E-pub date: 31 Aug 2016
Authors: AM Santangelo, M Ito, Y Shiba, HF Clarke, EH Schut, G Cockcroft, AC Ferguson-Smith, AC Roberts

Novel Primate Model of Serotonin Transporter Genetic Polymorphisms Associated with Gene Expression, Anxiety and Sensitivity to Antidepressants

DOI: http://doi.org/10.1038/npp.2016.41;
Journal: Neuropsychopharmacology
E-pub date: 21 Mar 2016
Authors: AM Santangelo, M Ito, Y Shiba, HF Clarke, EHS Schut, G Cockcroft, AC Ferguson-Smith, AC Roberts

Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion.

DOI: http://doi.org/10.1016/j.biopsych.2012.03.007
Journal: Biological Psychiatry
E-pub date: 15 Aug 2012
Authors: C Agustín-Pavón, K Braesicke, Y Shiba, AM Santangelo, Y Mikheenko, G Cockroft, F Asma, H Clarke, M-S Man, AC Roberts