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EMAIL bn246@cam.ac.uk
College King's College
Department
  • Clinical Neurosciences
    • Institute
  • John van Geest Centre for Brain Repair
  • Cambridge Institute for Medical Research
    • ORCID iDClick to view ORCID profile
    Research Theme Neurons, Circuits and Networks Lifelong Brain Development and Brain Ageing
    Research Focus

    Keywords

  • Ageing
  • Axon Regeneration
  • Axon Transport
  • Endoplasmic Reticulum
  • Gene Therapy
  • Integrins

    • Clinical Conditions

  • Spinal cord injury
  • Glaucoma

    • Equipment & Techniques

  • Cell culture
  • Immunohistochemistry
  • Microscopy
  • Other

    • Back

    Dr Bart Nieuwenhuis

    (he/him/his)
    University Position
    Research Associate

    Interests

    Injuries to the brain, spinal cord, and eyes have devastating consequences due to the limited regenerative capacity of adult neurons in the central nervous system (CNS). My research focuses on gene therapy and regenerative neurobiology, contributing to the following areas: 1) Developmental neurobiology: Investigating neuronal maturation and its impact on intrinsic axon growth. 2) Gene therapy: Optimising the delivery of transgenes to the nervous system using adeno-associated viral vectors. 3) Axon regeneration: Identifying and validating potential targets to promote axon regeneration in CNS neurons.

    The Axonal Growth Cone

    Key Publications

    Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells: comparison of five promoters.

    DOI: http://doi.org/10.1038/s41434-022-00380-z
    Journal: Gene Ther
    E-pub date: 1 Jun 2023
    Authors: B Nieuwenhuis, E Laperrousaz, JR Tribble, J Verhaagen, JW Fawcett, KR Martin, PA Williams, A Osborne

    Simple RGC: ImageJ plugins for counting retinal ganglion cells and determining the transduction efficiency of viral vectors in retinal wholemounts

    DOI: http://doi.org/10.5334/jors.342
    Journal: Journal of Open Research Software
    E-pub date: 9 Jun 2021
    Authors: T Cross, R Navarange, J-H Son, W Burr, A Singh, K Zhang, M Rusu, K Gkoutzis, A Osborne, B Nieuwenhuis

    Optimization of adeno-associated viral vector-mediated transduction of the corticospinal tract: comparison of four promoters.

    DOI: http://doi.org/10.1038/s41434-020-0169-1
    Journal: Gene Ther
    E-pub date: 1 Feb 2021
    Authors: B Nieuwenhuis, B Haenzi, S Hilton, A Carnicer-Lombarte, B Hobo, J Verhaagen, JW Fawcett

    PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS.

    DOI: http://doi.org/10.15252/emmm.201911674
    Journal: EMBO Mol Med
    E-pub date: 7 Aug 2020
    Authors: B Nieuwenhuis, AC Barber, RS Evans, CS Pearson, J Fuchs, AR MacQueen, S van Erp, B Haenzi, LA Hulshof, A Osborne, R Conceicao, TZ Khatib, SS Deshpande, J Cave, C Ffrench-Constant, PD Smith, K Okkenhaug, BJ Eickholt, KR Martin, JW Fawcett, R Eva

    Integrins promote axonal regeneration after injury of the nervous system.

    DOI: http://doi.org/10.1111/brv.12398
    Journal: Biol Rev Camb Philos Soc
    E-pub date: 31 Aug 2018
    Authors: B Nieuwenhuis, B Haenzi, MR Andrews, J Verhaagen, JW Fawcett

    Publications

    RABGAP1 acts as a sensor to facilitate sorting and processing of amyloid precursor protein

    DOI: http://doi.org/10.1101/2024.07.11.602925
    Journal:
    E-pub date: 1 Aug 2024
    Authors: J Eden, JGG Kaufman, J Cattin-Ortola, L Benedetti, B Nieuwenhuis, DJ Owen, J Lippincott-Schwartz, S Munro, DC Gershlick

    Intravitreal Injection of AAV for the Transduction of Mouse Retinal Ganglion Cells.

    DOI: http://doi.org/10.1007/978-1-0716-3409-7_17
    Journal:
    E-pub date: 1 Aug 2023
    Authors: B Nieuwenhuis, A Osborne

    Hyperactive PI3Kinase delta enables long distance regeneration of the rat corticospinal tract

    DOI: http://doi.org/10.1101/2023.10.27.564182
    Journal:
    E-pub date: 1 Aug 2023
    Authors: K Karova, Z Polcanova, S Suchankova, L Knight, B Nieuwenhuis, R Holota, V Herynek, LM Urdzikova, R Turecek, JCF Kwok, J Verhaagen, R Eva, JW Fawcett, P Jendelova

    Promoting axon regeneration in the central nervous system by increasing PI3-kinase signaling.

    DOI: http://doi.org/10.4103/1673-5374.327324
    Journal: Neural Regen Res
    E-pub date: 1 Jun 2022
    Authors: B Nieuwenhuis, R Eva

    Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1.

    DOI: http://doi.org/10.7554/eLife.72823
    Journal: Elife
    E-pub date: 6 Dec 2021
    Authors: A Loreto, C Angeletti, W Gu, A Osborne, B Nieuwenhuis, J Gilley, E Merlini, P Arthur-Farraj, A Amici, Z Luo, L Hartley-Tassell, T Ve, LM Desrochers, Q Wang, B Kobe, G Orsomando, MP Coleman

    Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing.

    DOI: http://doi.org/10.1038/s41380-021-01208-9
    Journal: Mol Psychiatry
    E-pub date: 1 Oct 2021
    Authors: S Yang, S Gigout, A Molinaro, Y Naito-Matsui, S Hilton, S Foscarin, B Nieuwenhuis, CL Tan, J Verhaagen, T Pizzorusso, LM Saksida, TM Bussey, H Kitagawa, JCF Kwok, JW Fawcett

    Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury.

    DOI: http://doi.org/10.3390/ijms22041798
    Journal: Int J Mol Sci
    E-pub date: 11 Feb 2021
    Authors: V Petrova, B Nieuwenhuis, JW Fawcett, R Eva

    ARF6 and Rab11 as intrinsic regulators of axon regeneration.

    DOI: http://doi.org/10.1080/21541248.2018.1457914
    Journal: Small GTPases
    E-pub date: 1 Nov 2020
    Authors: B Nieuwenhuis, R Eva

    Linking axon transport to regeneration using in vitro laser axotomy.

    DOI: http://doi.org/10.4103/1673-5374.228716
    Journal: Neural Regen Res
    E-pub date: 1 Mar 2018
    Authors: B Nieuwenhuis, R Eva

    A perspective on the role of class III semaphorin signaling in central nervous system trauma.

    DOI: http://doi.org/10.3389/fncel.2014.00328
    Journal: Front Cell Neurosci
    E-pub date: 1 Aug 2014
    Authors: V Mecollari, B Nieuwenhuis, J Verhaagen