Menu

College King's College
Research Focus

Keywords

  • Ageing
  • Axon Regeneration
  • Gene Therapy
  • Technology
  • Clinical Conditions

  • Glaucoma
  • Spinal cord injury
  • Equipment & Techniques

  • Other
  • Back

    Dr Bart Nieuwenhuis

    (he/him/his)
    University Position
    Other

    Interests

    As Innovation Pathway Manager (Proof-of-Concept) at Cambridge NeuroWorks and the University of Cambridge, my work focuses on supporting the translation of early-stage neurotechnology research towards proof-of-concept and future impact. Through the Blue Sky Proof-of-Concept Fund and Blue Sky Fellowship programme, I work with and support researchers developing innovative solutions to major challenges in neuroscience and neurotechnology, spanning areas including Parkinson's disease, mental health and emerging neurotechnologies. My research has focused on gene therapy and regenerative neurobiology, with particular interests in neuronal development, axon regeneration and gene delivery to the nervous system. Key research areas include: 1) Developmental neurobiology: Investigating neuronal maturation and its impact on intrinsic axon growth. 2) Gene therapy: Optimising the delivery of transgenes to the nervous system using adeno-associated viral vectors. 3) Axon regeneration: Identifying and validating potential targets to promote axon regeneration in CNS neurons.

    The Axonal Growth Cone

    Key Publications

    Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells: comparison of five promoters.

    DOI: http://doi.org/10.1038/s41434-022-00380-z
    Journal: Gene Ther
    E-pub date: 1 Jun 2023
    Authors: B Nieuwenhuis, E Laperrousaz, JR Tribble, J Verhaagen, JW Fawcett, KR Martin, PA Williams, A Osborne

    Simple RGC: ImageJ plugins for counting retinal ganglion cells and determining the transduction efficiency of viral vectors in retinal wholemounts

    DOI: http://doi.org/10.5334/jors.342
    Journal: Journal of Open Research Software
    E-pub date: 9 Jun 2021
    Authors: T Cross, R Navarange, J-H Son, W Burr, A Singh, K Zhang, M Rusu, K Gkoutzis, A Osborne, B Nieuwenhuis

    Optimization of adeno-associated viral vector-mediated transduction of the corticospinal tract: comparison of four promoters.

    DOI: http://doi.org/10.1038/s41434-020-0169-1
    Journal: Gene Ther
    E-pub date: 1 Feb 2021
    Authors: B Nieuwenhuis, B Haenzi, S Hilton, A Carnicer-Lombarte, B Hobo, J Verhaagen, JW Fawcett

    PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS.

    DOI: http://doi.org/10.15252/emmm.201911674
    Journal: EMBO Mol Med
    E-pub date: 7 Aug 2020
    Authors: B Nieuwenhuis, AC Barber, RS Evans, CS Pearson, J Fuchs, AR MacQueen, S van Erp, B Haenzi, LA Hulshof, A Osborne, R Conceicao, TZ Khatib, SS Deshpande, J Cave, C Ffrench-Constant, PD Smith, K Okkenhaug, BJ Eickholt, KR Martin, JW Fawcett, R Eva

    Integrins promote axonal regeneration after injury of the nervous system.

    DOI: http://doi.org/10.1111/brv.12398
    Journal: Biol Rev Camb Philos Soc
    E-pub date: 31 Aug 2018
    Authors: B Nieuwenhuis, B Haenzi, MR Andrews, J Verhaagen, JW Fawcett

    Publications

    RABGAP1 is a sensor that facilitates the sorting and processing of amyloid precursor protein.

    DOI: http://doi.org/10.1038/s44318-025-00530-0
    Journal: EMBO J
    E-pub date: 1 Oct 2025
    Authors: J Eden, JGG Kaufman, C Pereira, E Fox, J Cattin-Ortolá, L Benedetti, B Nieuwenhuis, DJ Owen, J Lippincott-Schwartz, S Munro, DC Gershlick

    Dose-ranging and further therapeutic evaluation of a bicistronic humanized TrkB-BDNF gene therapy for glaucoma in rodents.

    DOI: http://doi.org/10.1186/s44477-025-00003-y
    Journal: Mol Neurodegener Adv
    E-pub date: 1 Aug 2025
    Authors: A Osborne, TZ Khatib, M Whitehead, T Mensah, S Yazdouni, B Nieuwenhuis, Z Ali, J Ching, R Watt, N Kishi, N Kozono, JR Tribble, PS Widdowson, KR Martin

    Hyperactive delta isoform of PI3 kinase enables long-distance regeneration of adult rat corticospinal tract.

    DOI: http://doi.org/10.1016/j.ymthe.2024.12.040
    Journal: Mol Ther
    E-pub date: 5 Feb 2025
    Authors: K Karova, Z Polcanova, L Knight, S Suchankova, B Nieuwenhuis, R Holota, V Herynek, L Machova Urdzikova, R Turecek, JC Kwok, J van den Herik, J Verhaagen, R Eva, JW Fawcett, P Jendelova

    RABGAP1 acts as a sensor to facilitate sorting and processing of amyloid precursor protein

    DOI: http://doi.org/10.1101/2024.07.11.602925
    Journal:
    E-pub date: 14 Jul 2024
    Authors: J Eden, JGG Kaufman, J Cattin-Ortola, L Benedetti, B Nieuwenhuis, DJ Owen, J Lippincott-Schwartz, S Munro, DC Gershlick

    Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1.

    DOI: http://doi.org/10.7554/eLife.72823
    Journal: Elife
    E-pub date: 6 Dec 2021
    Authors: A Loreto, C Angeletti, W Gu, A Osborne, B Nieuwenhuis, J Gilley, E Merlini, P Arthur-Farraj, A Amici, Z Luo, L Hartley-Tassell, T Ve, LM Desrochers, Q Wang, B Kobe, G Orsomando, MP Coleman

    Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing.

    DOI: http://doi.org/10.1038/s41380-021-01208-9
    Journal: Mol Psychiatry
    E-pub date: 1 Oct 2021
    Authors: S Yang, S Gigout, A Molinaro, Y Naito-Matsui, S Hilton, S Foscarin, B Nieuwenhuis, CL Tan, J Verhaagen, T Pizzorusso, LM Saksida, TM Bussey, H Kitagawa, JCF Kwok, JW Fawcett

    Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury.

    DOI: http://doi.org/10.3390/ijms22041798
    Journal: Int J Mol Sci
    E-pub date: 11 Feb 2021
    Authors: V Petrova, B Nieuwenhuis, JW Fawcett, R Eva

    ARF6 and Rab11 as intrinsic regulators of axon regeneration.

    DOI: http://doi.org/10.1080/21541248.2018.1457914
    Journal: Small GTPases
    E-pub date: 1 Nov 2020
    Authors: B Nieuwenhuis, R Eva

    Linking axon transport to regeneration using in vitro laser axotomy.

    DOI: http://doi.org/10.4103/1673-5374.228716
    Journal: Neural Regen Res
    E-pub date: 1 Mar 2018
    Authors: B Nieuwenhuis, R Eva

    A perspective on the role of class III semaphorin signaling in central nervous system trauma.

    DOI: http://doi.org/10.3389/fncel.2014.00328
    Journal: Front Cell Neurosci
    E-pub date: 1 Aug 2014
    Authors: V Mecollari, B Nieuwenhuis, J Verhaagen