Professor Clemens Kaminski

University Position


We develop advanced microscopic imaging techniques that permit us to elucidate molecular mechanisms of neurodegeneration. We use techniques such as lifetime, spectrum and polarisation resolved imaging that inform on protein misfolding, aggregation and interaction in live cells and organisms. Recently we have been able to follow the aggregation of Alpha synuclein in a C elegans model of Parkinson's disease and were able to correlate the appearance of aggregates with toxic phenotypes. We have also set up an optical superresolution microscope in Cambridge, based on dSTORM (direct Stochastic Optical Reconstruction Microscopy) and this permits us to visualise morphology and size of toxic oligomers at a resolution down to 10 nm.

Key Publications

Protein Condensation, Cellular Organization, and Spatiotemporal Regulation of Cytoplasmic Properties.

Journal: Adv Biol (Weinh)
E-pub date: 1 Nov 2022
Authors: FW van Tartwijk, CF Kaminski

Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1

Journal: Cell
E-pub date: 19 Apr 2018
Authors: PH St George-Hyslop, S Qamar, G Wang, SJ Randle, FS Ruggeri, J Varela, CF Kaminski, GS Kaminski, M Vendruscolo, TPJ Knowles, D Klenerman, CE Holt, Q Lin, W meadows

Single Molecule Translation Imaging Visualizes the Dynamics of Local β-Actin Synthesis in Retinal Axons.

Journal: Sci Rep
E-pub date: 6 Apr 2017
Authors: F Ströhl, JQ Lin, RF Laine, HH-W Wong, V Urbančič, R Cagnetta, CE Holt, CF Kaminski

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function.

Journal: Neuron
E-pub date: 18 Nov 2015
Authors: T Murakami, S Qamar, JQ Lin, GSK Schierle, E Rees, A Miyashita, AR Costa, RB Dodd, FTS Chan, CH Michel, D Kronenberg-Versteeg, Y Li, S-P Yang, Y Wakutani, W Meadows, RR Ferry, L Dong, GG Tartaglia, G Favrin, W-L Lin, DW Dickson, M Zhen, D Ron, G Schmitt-Ulms, PE Fraser, NA Shneider, C Holt, M Vendruscolo, CF Kaminski, P St George-Hyslop


Mutation of the ALS/FTD-associated RNA-binding protein FUS alters axonal cytoskeletal organisation

E-pub date: 1 Aug 2022
Authors: F van Tartwijk, LCS Wunderlich, I Mela, S Makarchuk, MAH Jakobs, S Qamar, K Franze, GK Schierle, P St George-Hyslop, JQ Lin, C Holt, C Kaminski

The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes.

Journal: Sci Adv
E-pub date: 1 Dec 2020
Authors: M Lu, FW van Tartwijk, JQ Lin, W Nijenhuis, P Parutto, M Fantham, CN Christensen, E Avezov, CE Holt, A Tunnacliffe, D Holcman, L Kapitein, GSK Schierle, CF Kaminski

A waveguide imaging platform for live-cell TIRF imaging of neurons over large fields of view.

Journal: J Biophotonics
E-pub date: 1 Jun 2020
Authors: IS Opstad, F Ströhl, M Fantham, C Hockings, O Vanderpoorten, FW van Tartwijk, JQ Lin, J-C Tinguely, FT Dullo, GS Kaminski-Schierle, BS Ahluwalia, CF Kaminski

A protocol for single-molecule translation imaging in xenopus retinal ganglion cells

E-pub date: 1 Jan 2020
Authors: F Ströhl, JQ Lin, FW van Tartwijk, HHW Wong, CE Holt, CF Kaminski

On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons.

Journal: Cell Rep
E-pub date: 10 Dec 2019
Authors: T Shigeoka, M Koppers, HH-W Wong, JQ Lin, R Cagnetta, A Dwivedy, J de Freitas Nascimento, FW van Tartwijk, F Ströhl, J-M Cioni, J Schaeffer, M Carrington, CF Kaminski, H Jung, WA Harris, CE Holt

Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons.

Journal: Elife
E-pub date: 20 Nov 2019
Authors: M Koppers, R Cagnetta, T Shigeoka, LC Wunderlich, P Vallejo-Ramirez, J Qiaojin Lin, S Zhao, MA Jakobs, A Dwivedy, MS Minett, A Bellon, CF Kaminski, WA Harris, JG Flanagan, CE Holt

RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo.

Journal: Neuron
E-pub date: 16 Aug 2017
Authors: HH-W Wong, JQ Lin, F Ströhl, CG Roque, J-M Cioni, R Cagnetta, B Turner-Bridger, RF Laine, WA Harris, CF Kaminski, CE Holt

α-Synuclein – Regulator of Exocytosis, Endocytosis, or Both?

Journal: Trends Cell Biol
E-pub date: 1 Jul 2017
Authors: J Lautenschläger, CF Kaminski, GS Kaminski Schierle

Protein amyloids develop an intrinsic fluorescence signature during aggregation.

Journal: Analyst
E-pub date: 7 Apr 2013
Authors: FTS Chan, GS Kaminski Schierle, JR Kumita, CW Bertoncini, CM Dobson, CF Kaminski

Analysis of the native structure, stability and aggregation of biotinylated human lysozyme.

Journal: PLoS One
E-pub date: 1 Aug 2012
Authors: M Ahn, E De Genst, GS Kaminski Schierle, M Erdelyi, CF Kaminski, CM Dobson, JR Kumita

Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of alpha-synuclein aggregation.

Journal: J Mol Biol
E-pub date: 22 Jan 2010
Authors: TJ van Ham, A Esposito, JR Kumita, S-TD Hsu, GS Kaminski Schierle, CF Kaminski, CM Dobson, EAA Nollen, CW Bertoncini