• Psychiatry
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    Dr Deep Adhya

    University Position
    Research Associate


    We have recently shown that the in-vitro neural tube structure, the ?neural rosette? is affected in autism induced pluripotent stem cell (iPSC) derived neurons. This suggests that an autism diagnosis has genetic and epigenetic influences affecting atypical iPSC neural differentiation (Adhya et al 2021). We are currently studying gene regulatory pathways that cause atypical neural rosette formation in autism, focussing on the role of histone modifications and transcriptional activation. Specifically, we are investigating the role of the MLL/SET protein family on early neurodevelopment. We are also studying effects of genes and epigenome on neuronal outcomes using a 3D cerebral organoid approach. Finally, we are looking at the role of autism-associated sex chromosomal genes and sex hormones on transcriptional and epigenetic processes during 3D cerebral organoid development.

    Key Publications


    Application of Airy beam light sheet microscopy to examine early neurodevelopmental structures in 3D hiPSC-derived human cortical spheroids.

    Journal: Mol Autism
    E-pub date: 22 Jan 2021
    Authors: D Adhya, G Chennell, JA Crowe, EP Valencia-Alarcón, J Seyforth, NA Hosny, MV Yasvoina, R Forster, S Baron-Cohen, AC Vernon, DP Srivastava

    Environmental Pressures on Transgenerational Epigenetic Inheritance

    E-pub date: 19 Mar 2020
    Authors: D Adhya, A Massrali, A Paul, M Kotter, J Carroll, D Srivastava, J Price, S Baron-Cohen

    The epigenetics of autism

    E-pub date: 1 Jan 2019
    Authors: A Massrali, V Warrier, A Paul, D Adhya, DP Srivastava, M Kotter, S Baron-Cohen

    Atypical neurogenesis in induced pluripotent stem cell (iPSC) from autistic individuals

    E-pub date: 1 Aug 2018
    Authors: D Adhya, V Swarup, R Nagy, L Dutan, C Shum, E Valencia-Alarcón, KM Jozwik, MA Mendez, J Horder, E Loth, P Nowosiad, I Lee, D Skuse, F Flinter, D Murphy, G McAlonan, D Geschwind, J Price, J Carroll, D Srivastava, S Baron-Cohen

    Understanding the role of steroids in typical and atypical brain development: Advantages of using a “brain in a dish” approach.

    Journal: J Neuroendocrinol
    E-pub date: 1 Feb 2018
    Authors: D Adhya, E Annuario, MA Lancaster, J Price, S Baron-Cohen, DP Srivastava