Dr Daniel Rainbow

University Position

Research Associate

Interests

I am using single cell RNA-sequencing to understand the immune system within blood and CSF of patients with neuroimmune conditions .

Key Publications

The MS Remyelinating Drug Bexarotene (an RXR Agonist) Promotes Induction of Human Tregs and Suppresses Th17 Differentiation In Vitro.

DOI: http://doi.org/10.3389/fimmu.2021.712241
Journal: Front Immunol
E-pub date: 1 Aug 2021
Authors: CM Gaunt, DB Rainbow, RJ Mackenzie, LB Jarvis, HS Mousa, N Cunniffe, Z Georgieva, JW Brown, AJ Coles, JL Jones

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

DOI: http://doi.org/10.1172/jci.insight.93739
Journal: JCI Insight
E-pub date: 17 Aug 2017
Authors: ML Pekalski, AR García, RC Ferreira, DB Rainbow, DJ Smyth, M Mashar, J Brady, N Savinykh, XC Dopico, S Mahmood, S Duley, HE Stevens, NM Walker, AJ Cutler, F Waldron-Lynch, DB Dunger, C Shannon-Lowe, AJ Coles, JL Jones, C Wallace, JA Todd, LS Wicker

Cross-tissue immune cell analysis reveals tissue-specific features in humans

DOI: https://doi.org/10.1126/science.abl5197
Journal: Science
Year: 2022
Authors: C. Domínguez Conde†, C. Xu†, L. B. Jarvis†, D. B. Rainbow†, S. B. Wells†, T. Gomes, S. K. Howlett, O. Suchanek, K. Polanski, H. W. King, L. Mamanova, N. Huang, P. A. Szabo, L. Richardson, L. Bolt, E. S. Fasouli, K. T. Mahbubani, M. Prete, L. Tuck, N. Richoz, Z. K. Tuong, L. Campos, H. S. Mousa, E. J. Needham, S. Pritchard, T. Li, R. Elmentaite, J. Park, E. Rahmani, D. Chen, D. K. Menon, O. A. Bayraktar, L. K. James, K. B. Meyer, N. Yosef, M. R. Clatworthy, P. A. Sims, D. L. Farber, K. Saeb-Parsy*‡, J. L. Jones*‡, S. A. Teichmann*‡

Publications

Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.

DOI: http://doi.org/10.1038/s42003-021-02721-x
Journal: Commun Biol
E-pub date: 14 Oct 2021
Authors: LB Jarvis, DB Rainbow, V Coppard, SK Howlett, Z Georgieva, JL Davies, HK Mullay, J Hester, T Ashmore, A Van Den Bosch, JT Grist, AJ Coles, HS Mousa, S Pluchino, KT Mahbubani, JL Griffin, K Saeb-Parsy, F Issa, L Peruzzotti-Jametti, LS Wicker, JL Jones

The MS remyelinating drug bexarotene (an RXR agonist) promotes induction of human Tregs and suppresses Th17 differentiation in vitro

DOI: http://doi.org/10.1101/2021.02.17.431344
Journal:
E-pub date: 17 Feb 2021
Authors: C Gaunt, D Rainbow, R Mackenzie, L Jarvis, H Mousa, N Cunniffe, Z Georgieva, W Brown, A Coles, J Jones

Therapeutically expanded human regulatory T-cells are super- suppressive due to HIF1A induced expression of CD73.

DOI: http://doi.org/10.21203/rs.3.rs-92789/v1
Journal:
E-pub date: 23 Nov 2020
Authors: L Jarvis, D Rainbow, V Coppard, S Howlett, J Davies, H Mullay, J Hester, T Ashmore, AVD Bosch, J Grist, A Coles, H Mousa, S Pluchino, K Mahbubani, J Griffin, K Saeb-Parsy, F Issa, L Peruzzotti-Jametti, L Wicker, J Jones

Keratinocyte growth factor impairs human thymic recovery from lymphopenia.

DOI: http://doi.org/10.1172/jci.insight.125377
Journal: JCI Insight
E-pub date: 7 May 2019
Authors: AJ Coles, L Azzopardi, O Kousin-Ezewu, HK Mullay, SA Thompson, L Jarvis, J Davies, S Howlett, D Rainbow, J Babar, TJ Sadler, JWL Brown, E Needham, K May, ZG Georgieva, AE Handel, S Maio, M Deadman, I Rota, G Holländer, S Dawson, D Jayne, R Seggewiss-Bernhardt, DC Douek, JD Isaacs, JL Jones