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Department
  • Zoology
  • Research Focus

    Keywords

  • Drosophila Neurogenetics
  • Mitochondria
  • Brain Development
  • Neural Regeneration
  • Equipment & Techniques

  • Confocal microscopy
  • Immunohistochemistry
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    Dr Daniel Sobrido-Cameán

    (he/him/his)
    University Position
    Research Associate

    Interests

    During my PhD, I have been carrying out studies using lampreys as an animal model for spinal cord injury. Lampreys are a good model of regeneration/plasticity. But, also has some limitations. For example, their life cycle takes between 5 and 7 years from birth to sexual maturity. Therefore, it is highly impractical to generate stable mutant or transgenic lines in the laboratory. In contrast to lampreys, the fruit-fly, Drosophila, is genetically tractable and there are tools and innovations in genetic, imaging, and electrophysiological technologies that have enabled the visualization, in vivo, of dynamic processes such as dendritic growth and synapse development. For this reason, I joined to the group of Dr Matthias Landgraf, who has extensive experience in the use of drosophila as a model for the study of the development of the nervous system. In the long run, I want to harness the genetics of Drosophila to identify candidate pathways and genes involved in nervous system development.

    Key Publications

    Activity-regulated growth of motoneurons at the neuromuscular junction is mediated by NADPH oxidases.

    DOI: http://doi.org/10.3389/fncel.2022.1106593
    Journal: Front Cell Neurosci
    E-pub date: 1 Aug 2022
    Authors: D Sobrido-Cameán, MCW Oswald, DMD Bailey, A Mukherjee, M Landgraf

    Inhibition of Gamma-Secretase Promotes Axon Regeneration After a Complete Spinal Cord Injury.

    DOI: http://doi.org/10.3389/fcell.2020.00173
    Journal: Front Cell Dev Biol
    E-pub date: 1 Aug 2020
    Authors: D Sobrido-Cameán, D Robledo, D Romaus-Sanjurjo, V Pérez-Cedrón, L Sánchez, MC Rodicio, A Barreiro-Iglesias

    Taurine promotes axonal regeneration after a complete spinal cord injury in lampreys

    DOI: http://doi.org/10.1101/655191
    Journal:
    E-pub date: 1 Aug 2019
    Authors: D Sobrido-Cameán, B Fernández-López, N Pereiro, A Lafuente, MC Rodicio, A Barreiro-Iglesias

    Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys.

    DOI: http://doi.org/10.1242/dmm.037085
    Journal: Dis Model Mech
    E-pub date: 20 Feb 2019
    Authors: D Sobrido-Cameán, D Robledo, L Sánchez, MC Rodicio, A Barreiro-Iglesias

    Publications

    Spontaneous regeneration of cholecystokinergic reticulospinal axons after a complete spinal cord injury in sea lampreys

    DOI: http://doi.org/10.1016/j.csbj.2023.12.014
    Journal: Comput Struct Biotechnol J
    E-pub date: 1 Dec 2024
    Authors: L González-Llera, GN Santos-Durán, D Sobrido-Cameán, C Núñez-González, J Pérez-Fernández, A Barreiro-Iglesias

    An in vivo drug screen in zebrafish reveals that cyclooxygenase 2-derived prostaglandin D2 promotes spinal cord neurogenesis.

    DOI: http://doi.org/10.1111/cpr.13594
    Journal: Cell Prolif
    E-pub date: 1 May 2024
    Authors: L González-Llera, D Sobrido-Cameán, A Quelle-Regaldie, L Sánchez, A Barreiro-Iglesias

    A lamprey neural cell type atlas illuminates the origins of the vertebrate brain.

    DOI: http://doi.org/10.1038/s41559-023-02170-1
    Journal: Nat Ecol Evol
    E-pub date: 1 Oct 2023
    Authors: F Lamanna, F Hervas-Sotomayor, AP Oel, D Jandzik, D Sobrido-Cameán, GN Santos-Durán, ML Martik, J Stundl, SA Green, T Brüning, K Mößinger, J Schmidt, C Schneider, M Sepp, F Murat, JJ Smith, ME Bronner, MC Rodicio, A Barreiro-Iglesias, DM Medeiros, D Arendt, H Kaessmann

    Publisher Correction: A lamprey neural cell type atlas illuminates the origins of the vertebrate brain.

    DOI: http://doi.org/10.1038/s41559-023-02227-1
    Journal: Nat Ecol Evol
    E-pub date: 1 Oct 2023
    Authors: F Lamanna, F Hervas-Sotomayor, AP Oel, D Jandzik, D Sobrido-Cameán, GN Santos-Durán, ML Martik, J Stundl, SA Green, T Brüning, K Mößinger, J Schmidt, C Schneider, M Sepp, F Murat, JJ Smith, ME Bronner, MC Rodicio, A Barreiro-Iglesias, DM Medeiros, D Arendt, H Kaessmann

    Activity-regulated growth of motoneurons at the neuromuscular junction is mediated by NADPH oxidases

    DOI: http://doi.org/10.1101/2022.10.27.514147
    Journal:
    E-pub date: 1 Aug 2022
    Authors: D Sobrido-Cameán, M Oswald, D Bailey, A Mukherjee, M Landgraf

    Full regeneration of descending corticotropin-releasing hormone axons after a complete spinal cord injury in lampreys.

    DOI: http://doi.org/10.1016/j.csbj.2022.10.020
    Journal: Comput Struct Biotechnol J
    E-pub date: 1 Aug 2022
    Authors: L González-Llera, D Sobrido-Cameán, GN Santos-Durán, A Barreiro-Iglesias

    A nop56 Zebrafish Loss-of-Function Model Exhibits a Severe Neurodegenerative Phenotype.

    DOI: http://doi.org/10.3390/biomedicines10081814
    Journal: Biomedicines
    E-pub date: 28 Jul 2022
    Authors: A Quelle-Regaldie, M Folgueira, J Yáñez, D Sobrido-Cameán, A Alba-González, A Barreiro-Iglesias, M-J Sobrido, L Sánchez

    Morpholino studies shed light on the signaling pathways regulating axon regeneration in lampreys.

    DOI: http://doi.org/10.4103/1673-5374.330597
    Journal: Neural Regen Res
    E-pub date: 1 Jul 2022
    Authors: D Sobrido-Camean, A Barreiro-Iglesias

    Reconstructing the ancestral vertebrate brain using a lamprey neural cell type atlas

    DOI: http://doi.org/10.1101/2022.02.28.482278
    Journal:
    E-pub date: 1 Mar 2022
    Authors: F Lamanna, F Hervas-Sotomayor, AP Oel, D Jandzik, D Sobrido-Cameán, ML Martik, SA Green, T Brüning, K Mößinger, J Schmidt, C Schneider, M Sepp, F Murat, JJ Smith, ME Bronner, MC Rodicio, A Barreiro-Iglesias, DM Medeiros, D Arendt, H Kaessmann

    Expression of Kisspeptin 1 in the Brain of the Adult Sea Lamprey Petromyzon marinus.

    DOI: http://doi.org/10.3390/life11111174
    Journal: Life (Basel)
    E-pub date: 3 Nov 2021
    Authors: D Sobrido-Cameán, LA Yáñez-Guerra, A Deber, MC Rodicio, A Barreiro-Iglesias

    Expression of Urocortin 3 mRNA in the Central Nervous System of the Sea Lamprey Petromyzon marinus.

    DOI: http://doi.org/10.3390/biology10100978
    Journal: Biology (Basel)
    E-pub date: 28 Sep 2021
    Authors: D Sobrido-Cameán, R Anadón, A Barreiro-Iglesias

    Differential expression of somatostatin genes in the central nervous system of the sea lamprey.

    DOI: http://doi.org/10.1007/s00429-021-02224-9
    Journal: Brain Struct Funct
    E-pub date: 1 May 2021
    Authors: D Sobrido-Cameán, LA Yáñez-Guerra, A Deber, M Freire-Delgado, R Cacheiro-Vázquez, MC Rodicio, H Tostivint, R Anadón, A Barreiro-Iglesias

    Zebrafish Models of Autosomal Dominant Ataxias.

    DOI: http://doi.org/10.3390/cells10020421
    Journal: Cells
    E-pub date: 17 Feb 2021
    Authors: A Quelle-Regaldie, D Sobrido-Cameán, A Barreiro-Iglesias, MJ Sobrido, L Sánchez

    Differential expression of five prosomatostatin genes in the central nervous system of the catshark Scyliorhinus canicula.

    DOI: http://doi.org/10.1002/cne.24898
    Journal: J Comp Neurol
    E-pub date: 1 Oct 2020
    Authors: D Sobrido-Cameán, H Tostivint, S Mazan, MC Rodicio, I Rodríguez-Moldes, E Candal, R Anadón, A Barreiro-Iglesias

    Developmentally-programmed cellular senescence is conserved and widespread in zebrafish.

    DOI: http://doi.org/10.18632/aging.103968
    Journal: Aging (Albany NY)
    E-pub date: 29 Sep 2020
    Authors: S Da Silva-Álvarez, J Guerra-Varela, D Sobrido-Cameán, A Quelle, A Barreiro-Iglesias, L Sánchez, M Collado

    Taurine Promotes Axonal Regeneration after a Complete Spinal Cord Injury in Lampreys.

    DOI: http://doi.org/10.1089/neu.2019.6604
    Journal: J Neurotrauma
    E-pub date: 15 Mar 2020
    Authors: D Sobrido-Cameán, B Fernández-López, N Pereiro, A Lafuente, MC Rodicio, A Barreiro-Iglesias

    Cell senescence contributes to tissue regeneration in zebrafish.

    DOI: http://doi.org/10.1111/acel.13052
    Journal: Aging Cell
    E-pub date: 1 Jan 2020
    Authors: S Da Silva-Álvarez, J Guerra-Varela, D Sobrido-Cameán, A Quelle, A Barreiro-Iglesias, L Sánchez, M Collado

    Cholecystokinin in the central nervous system of the sea lamprey Petromyzon marinus: precursor identification and neuroanatomical relationships with other neuronal signalling systems.

    DOI: http://doi.org/10.1007/s00429-019-01999-2
    Journal: Brain Struct Funct
    E-pub date: 1 Jan 2020
    Authors: D Sobrido-Cameán, LA Yáñez-Guerra, D Robledo, E López-Varela, MC Rodicio, MR Elphick, R Anadón, A Barreiro-Iglesias

    Differential expression of five prosomatostatin genes in the central nervous system of the catsharkScyliorhinus canicula

    DOI: http://doi.org/10.1101/823187
    Journal:
    E-pub date: 1 Aug 2019
    Authors: D Sobrido-Cameán, H Tostivint, S Mazan, MC Rodicio, I Rodríguez-Moldes, E Candal, R Anadón, A Barreiro-Iglesias

    Galanin in an Agnathan: Precursor Identification and Localisation of Expression in the Brain of the Sea Lamprey Petromyzon marinus.

    DOI: http://doi.org/10.3389/fnana.2019.00083
    Journal: Front Neuroanat
    E-pub date: 1 Aug 2019
    Authors: D Sobrido-Cameán, LA Yáñez-Guerra, F Lamanna, C Conde-Fernández, H Kaessmann, MR Elphick, R Anadón, MC Rodicio, A Barreiro-Iglesias

    First person – Daniel Sobrido-Camean

    DOI: http://doi.org/10.1242/dmm.039214
    Journal: DISEASE MODELS & MECHANISMS
    E-pub date: 1 Aug 2019
    Authors: D Sobrido-Camean

    Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys

    DOI: http://doi.org/10.1101/335844
    Journal:
    E-pub date: 1 Aug 2018
    Authors: D Sobrido-Cameán, D Robledo, L Sánchez, MC Rodicio, A Barreiro-Iglesias

    Role of Caspase-8 and Fas in Cell Death After Spinal Cord Injury.

    DOI: http://doi.org/10.3389/fnmol.2018.00101
    Journal: Front Mol Neurosci
    E-pub date: 1 Aug 2018
    Authors: D Sobrido-Cameán, A Barreiro-Iglesias

    Serotonin controls axon and neuronal regeneration in the nervous system: lessons from regenerating animal models.

    DOI: http://doi.org/10.4103/1673-5374.226387
    Journal: Neural Regen Res
    E-pub date: 1 Feb 2018
    Authors: D Sobrido-Cameán, MC Rodicio, A Barreiro-Iglesias

    Retrograde Activation of the Extrinsic Apoptotic Pathway in Spinal-Projecting Neurons after a Complete Spinal Cord Injury in Lampreys.

    DOI: http://doi.org/10.1155/2017/5953674
    Journal: Biomed Res Int
    E-pub date: 1 Aug 2017
    Authors: A Barreiro-Iglesias, D Sobrido-Cameán, MI Shifman

    Cloning of the GABAB Receptor Subunits B1 and B2 and their Expression in the Central Nervous System of the Adult Sea Lamprey.

    DOI: http://doi.org/10.3389/fnana.2016.00118
    Journal: Front Neuroanat
    E-pub date: 1 Aug 2016
    Authors: D Romaus-Sanjurjo, B Fernández-López, D Sobrido-Cameán, A Barreiro-Iglesias, MC Rodicio