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Research Focus

Keywords

  • Ion Channels
  • Behaviour
  • Neuronal Plasticity
  • Calcium Imaging
  • Caenorhabditis Elegans
  • Clinical Conditions

  • Chronic pain
  • Autism
  • Equipment & Techniques

  • Calcium imaging
  • Behavioural analysis
  • Science Culture

  • Public Outreach
  • Science Communication
  • Equality, Diversity, Inclusion and Wellbeing
  • Back

    Dr Denise Walker

    (she/her/hers)
    University Position
    Senior Investigator Scientist

    Interests

    Senior Scientist, MRC Laboratory of Molecular Biology. Molecular and circuit basis of mechanosensation; the molecules responsible (innexins, degenerin/epithelial Na+ channels (DEG/ENaCs)) and protein interactions that modulate their function. Channel properties and cellular and behavioural functions of DEG/ENaCs, particularly with respect to the role of protons in cell signalling and plasticity. Outreach activities: "Worms are cleverer than you think" science festival/primary school activity (https://www3.mrc-lmb.cam.ac.uk/sites/cambridgefestival/worms/); Science/Dance collaboration; hosting work experience students. FOR A FULL LIST OF PUBLICATIONS: https://scholar.google.com/citations?hl=en&user=69tm2zwAAAAJ

    Collaborators

    External
  • Key Publications

    Physiological insight into the conserved properties of Caenorhabditis elegans acid-sensing degenerin/epithelial sodium channels

    DOI:
    Journal: J Physiol.
    Year: 2023
    Authors: Eva Kaulich, Patrick T N McCubbin, William R Schafer, Denise S Walker

    Distinct roles for two Caenorhabditis elegans acid-sensing ion channels in an ultradian clock

    DOI:
    Journal: Elife
    Year: 2022
    Authors: Eva Kaulich, Trae Carroll, Brian D Ackley, Yi-Quan Tang, Iris Hardege, Keith Nehrke, William R Schafer, Denise S Walker

    Distinct roles for innexin gap junctions and hemichannels in mechanosensation

    DOI:
    Journal: Elife
    Year: 2020
    Authors: Denise S Walker, William R Schafer

    Network control principles predict neuron function in the Caenorhabditis elegans connectome

    DOI:
    Journal: Nature
    Year: 2017
    Authors: Gang Yan, Petra E Vértes, Emma K Towlson, Yee Lian Chew, Denise S Walker, William R Schafer, Albert-László Barabási

    Publications