• Medical Genetics
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    Dr Evan Reid

    University Position
    Wellcome Trust Senior Research Fellow


    My group's research is focussed on the hereditary spastic paraplegias, genetic conditions where the corticospinal tract axons degenerate. HSPs selectively involve axons while sparing the neuronal cell bodies, so we study them to understand molecular mechanisms crucial for axonal maintenance and degeneration. Our research has evolved from gene mapping and identification studies to concentrate on cell biological studies, particularly in the area of the role of HSP proteins in membrane traffic. The overall aim of this research is to understand the normal function of selected HSP proteins, to determine how abnormality of these functions leads to the disease, and to use this knowledge to rationally design new therapeutic strategies for the disorder.

    Key Publications

    Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS.

    Journal: Nat Commun
    E-pub date: 5 Nov 2020
    Authors: V Petrova, CS Pearson, J Ching, JR Tribble, AG Solano, Y Yang, FM Love, RJ Watt, A Osborne, E Reid, PA Williams, KR Martin, HM Geller, R Eva, JW Fawcett


    [11C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease.

    Journal: Neurology
    E-pub date: 21 Apr 2021
    Authors: J van den Ameele, Y Hong, R Manavaki, A Kouli, H Biggs, Z MacIntyre, R Horvath, P Yu-Wai-Man, E Reid, CH Williams-Gray, E Bullmore, F Aigbirhio, T Fryer, P Chinnery