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College Trinity College
Department
  • Clinical Neurosciences
    • School
  • Clinical Medicine
    • Institute
  • John van Geest Centre for Brain Repair
    • Research Theme Neurons, Circuits and Networks
    Research Focus

    Keywords

  • Wallerian Degeneration
  • Axon & Neuronal Degeneration
  • NAD

    • Clinical Conditions

  • Motor neurone disease

    • Equipment & Techniques

  • Cell culture
  • Enzyme assays
  • Microscopy
  • Protein purification

    • Science Culture

  • Women in Neuroscience
  • Green Neuroscience

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    Eleanor Hopkins

    (she/her/hers)
    University Position
    PhD student

    Interests

    I am doing a BBSRC Collaborative Training Partnership PhD Studentship in the lab of Prof Michael Coleman. Project outline: Investigating the structural basis of SARM1 activation, a NAD-degrading enzyme that drives axon degeneration. Work focuses on characterising the SARM1 ARM domain allosteric site, investigating a rare natural SARM1 variant found in a patient with developmental and retinal symptoms, and determining the protein structure of SARM1 ARM domain variants using cryo-EM, in collaboration with AstraZeneca, who part funded my PhD.

    Key Publications

    A Novel NAD Signaling Mechanism in Axon Degeneration and its Relationship to Innate Immunity.

    DOI: http://doi.org/10.3389/fmolb.2021.703532
    Journal: Front Mol Biosci
    E-pub date: 1 Aug 2021
    Authors: EL Hopkins, W Gu, B Kobe, MP Coleman

    Publications

    Cultured dissociated primary dorsal root ganglion neurons from adult horses enable study of axonal transport.

    DOI: https://doi.org/10.1111/joa.13719
    Journal: Journal of Anatomy
    Year: 2022
    Authors: Adalbert, R., Cahalan, S., Hopkins, E. L., Almuhanna, A., Loreto, A., Pór, E., Körmöczy, L., Perkins, J., Coleman, M. P., & Piercy, R. J.