College Trinity College
Research Focus


  • Wallerian Degeneration
  • Axon & Neuronal Degeneration
  • NAD
  • Clinical Conditions

  • Motor neurone disease
  • Equipment & Techniques

  • Cell culture
  • Enzyme assays
  • Microscopy
  • Protein purification
  • Science Culture

  • Women in Neuroscience
  • Green Neuroscience
  • Back

    Eleanor Hopkins

    University Position
    PhD student


    I am doing a BBSRC Collaborative Training Partnership PhD Studentship in the lab of Prof Michael Coleman. Project outline: Investigating the structural basis of SARM1 activation, a NAD-degrading enzyme that drives axon degeneration. Work focuses on characterising the SARM1 ARM domain allosteric site, investigating a rare natural SARM1 variant found in a patient with developmental and retinal symptoms, and determining the protein structure of SARM1 ARM domain variants using cryo-EM, in collaboration with AstraZeneca, who part funded my PhD.

    Key Publications

    A Novel NAD Signaling Mechanism in Axon Degeneration and its Relationship to Innate Immunity.

    Journal: Front Mol Biosci
    E-pub date: 1 Aug 2021
    Authors: EL Hopkins, W Gu, B Kobe, MP Coleman


    Cultured dissociated primary dorsal root ganglion neurons from adult horses enable study of axonal transport.

    Journal: Journal of Anatomy
    Year: 2022
    Authors: Adalbert, R., Cahalan, S., Hopkins, E. L., Almuhanna, A., Loreto, A., Pór, E., Körmöczy, L., Perkins, J., Coleman, M. P., & Piercy, R. J.