College Clare Hall
Research Focus


  • 11C-Carbon
  • Alzheimer's Disease
  • Brain Stimulation
  • Neurodegenerative Dementia
  • Clinical Neurosciences
  • Clinical Conditions

  • Alzheimer's disease
  • Equipment & Techniques

  • Positron Emission Tomography (PET)
  • Back

    Dr Emad Sidhom MBBCh, ABPsych, MRCPsych

    University Position
    Clinical Research Associate


    I am interested in neurodegenerative disorders, in particular Alzheimer's Disease. I work to understand the pathological mechanisms underlying neurodegenerative processes. I aim to search for the failure of synaptic repair and modify the unfolded protein response in the endoplasmic reticulum. The aim is to achieve a safe neuroprotective, disease modifying agent to slow down the progress of neurocognitive disorders. Electroconvulsive Therapy (ECT) and other forms of neuromodulation in psychiatry is my other area of clinical interest which include research on the low pulse amplitude (< 800 mA), ultra-brief pulse (<0.5 ms) unilateral (ECT) usage to minimise the cognitive side effects of ECT while retaining its efficacy. As well as, optimising titration schedules and algorithms of ECT dosing strategies, and understanding the mechanism of action of ECT, and the mechanism by which ECT causes adverse event in order to provide safe and effective targeted delivery of ECT.


  • Ben Underwood
  • Key Publications


    195. Predicting Patients With Dementia Most at Risk of Needing Psychiatric Inpatient or Enhanced Community Care Using Routinely Collected Clinical Data

    Journal: Biological Psychiatry
    E-pub date: 1 May 2023
    Authors: S London, S Chen, E Sidhom, J Lewis, R Cardinal, D Roalf, B Underwood

    The epidemiology and clinical features of personality disorders in later life; a study of secondary care data.

    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Dec 2022
    Authors: N Treagust, E Sidhom, J Lewis, C Denman, O Knutson, BR Underwood

    Trazodone and patient outcomes in dementia-Limitations of naturalistic cohort data.

    Journal: Int J Geriatr Psychiatry
    E-pub date: 31 Aug 2022
    Authors: E Sidhom, MS Padilla, J Lewis, S White, JT O'Brien, GR Mallucci, BR Underwood

    Targeting the Unfolded Protein Response as a Disease-Modifying Pathway in Dementia

    Journal: International Journal of Molecular Sciences
    E-pub date: 11 Feb 2022
    Authors: E Sidhom, JT O’Brien, AJ Butcher, HL Smith, GR Mallucci, BR Underwood

    Patient and clinician experience of providing remote memory assessment services.

    Journal: Int J Geriatr Psychiatry
    E-pub date: 5 Dec 2021
    Authors: A Aftab, E Sidhom, A Forrest, N Judge, BR Underwood, K Harkness, DJ Blackburn

    Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom.

    Journal: Clin Trials
    E-pub date: 1 Oct 2021
    Authors: ME Török, BR Underwood, M Toshner, C Waddington, E Sidhom, K Sharrocks, R Bousfield, C Summers, C Saunders, Z McIntyre, H Morris, J Piper, G Calderon, S Dennis, T Assari, AM de Rotrou, A Shaw, J Bradley, J O'Brien, RC Rintoul, I Smith, E Bullmore, K Chatterjee, Cambridge COVID Vaccine Trial Team

    Providing memory assessment services during COVID-19.

    Journal: Aging Ment Health
    E-pub date: 31 Aug 2021
    Authors: BR Underwood, A Thompsell, E Sidhom, A Burns

    The Nomenclature of Electroconvulsive Therapy.

    Journal: J ECT
    E-pub date: 1 Jun 2021
    Authors: E Sidhom, MH Omar

    Case report: delayed response after electroconvulsive therapy in a patient with major depressive disorder.

    Journal: BMC Psychiatry
    E-pub date: 21 Jan 2021
    Authors: F Chen, E Sidhom, S Yang, E Ruiz-Mendoza, J Essem

    Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.

    Journal: Lancet
    E-pub date: 9 Jan 2021
    Authors: M Voysey, SAC Clemens, SA Madhi, LY Weckx, PM Folegatti, PK Aley, B Angus, VL Baillie, SL Barnabas, QE Bhorat, S Bibi, C Briner, P Cicconi, AM Collins, R Colin-Jones, CL Cutland, TC Darton, K Dheda, CJA Duncan, KRW Emary, KJ Ewer, L Fairlie, SN Faust, S Feng, DM Ferreira, A Finn, AL Goodman, CM Green, CA Green, PT Heath, C Hill, H Hill, I Hirsch, SHC Hodgson, A Izu, S Jackson, D Jenkin, CCD Joe, S Kerridge, A Koen, G Kwatra, R Lazarus, AM Lawrie, A Lelliott, V Libri, PJ Lillie, R Mallory, AVA Mendes, EP Milan, AM Minassian, A McGregor, H Morrison, YF Mujadidi, A Nana, PJ O'Reilly, SD Padayachee, A Pittella, E Plested, KM Pollock, MN Ramasamy, S Rhead, AV Schwarzbold, N Singh, A Smith, R Song, MD Snape, E Sprinz, RK Sutherland, R Tarrant, EC Thomson, ME Török, M Toshner, DPJ Turner, J Vekemans, TL Villafana, MEE Watson, CJ Williams, AD Douglas, AVS Hill, T Lambe, SC Gilbert, AJ Pollard, Oxford COVID Vaccine Trial Group

    The Depiction of ECT in Egyptian Media

    Journal: Biomedical Journal of Scientific & Technical Research
    E-pub date: 29 Sep 2020
    Authors: E Sidhom

    The application of stratified medicine to dementia care

    Journal: BJPsych Advances
    E-pub date: 1 Jul 2020
    Authors: E Sidhom, J O'Brien, BR Underwood

    Brain Stimulation the 21st Century Speciality

    Journal: Journal of Psychology, Neuropsychiatric disorders and Brain Stimulation
    E-pub date: 18 Jul 2016
    Authors: E Sidhom

    Patients’ Perspectives on Stigma of Mental Illness (an Egyptian Study in a Private Hospital).

    Journal: Front Psychiatry
    E-pub date: 1 Aug 2014
    Authors: E Sidhom, A Abdelfattah, JM Carter, A El-Dosoky, MF El-Islam

    Ultra-brief pulse unilateral ECT is associated with less cognitive side effects.

    Journal: Brain Stimul
    E-pub date: 1 Aug 2014
    Authors: E Sidhom, NA Youssef

    The impact of the uprising in Egypt on mental health in a private hospital

    Journal: International Psychiatry
    E-pub date: 1 Nov 2012
    Authors: E Sidhom

    The experience of stigma among a sample of psychiatric in-patients in an Egyptian private psychiatric hospital

    Journal: International Psychiatry
    E-pub date: 1 May 2012
    Authors: E Sidhom, A Abdelfattah, AR El-Dosoky, JM Carter, MF El-Islam

    Interface between Liaison Psychiatry Services for Older People and Wider Community Services

    Journal: Tadros G, Crowther G, eds. Handbook of Old Age Liaison Psychiatry.
    Year: 2024
    Authors: BR Underwood, R Tandy , E Sidhom.