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Department
  • Clinical Biochemistry
    • Institute
  • Wellcome – MRC Institute of Metabolic Science
    • Research Theme Neurons, Circuits and Networks
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    Dr Frank Reimann

    University Position
    Professor

    Interests

    Research in the lab is currently focusing on enteroendocrine cells, especially glucagon-like peptide-1 (GLP-1) secreting cells, which we hope to target in the treatment of diabetes and obesity. GLP-1 secreting cells are electrically excitable and respond to changes in ambient nutrient supply through electrogenic uptake and an increase in action potential firing frequency. We also started to work on GLP-1 target cells including enteric and affarent autonomic neurons. In addition we have a longstanding interest in nociception, characterising ion channel mutations found by Geoff Woods group in inherited pain disorders.

    Key Publications

    Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel KV6.4 Subunit.

    DOI: http://doi.org/10.1016/j.celrep.2020.107941
    Journal: Cell Rep
    E-pub date: 21 Jul 2020
    Authors: MC Lee, MS Nahorski, JRF Hockley, VB Lu, G Ison, LA Pattison, G Callejo, K Stouffer, E Fletcher, C Brown, I Drissi, D Wheeler, P Ernfors, D Menon, F Reimann, ESJ Smith, CG Woods

    Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis.

    DOI: http://doi.org/10.1016/j.molmet.2018.08.006
    Journal: Mol Metab
    E-pub date: 1 Nov 2018
    Authors: P Kirwan, RG Kay, B Brouwers, V Herranz-Pérez, M Jura, P Larraufie, J Jerber, J Pembroke, T Bartels, A White, FM Gribble, F Reimann, IS Farooqi, S O'Rahilly, FT Merkle

    Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.

    DOI: http://doi.org/10.1007/s00125-016-4033-1
    Journal: Diabetologia
    E-pub date: 1 Oct 2016
    Authors: AE Adriaenssens, B Svendsen, BYH Lam, GSH Yeo, JJ Holst, F Reimann, FM Gribble

    Publications

    Obesity medication lorcaserin requires brainstem GLP-1 neurons to reduce food intake in mice

    DOI: http://doi.org/10.1101/2022.05.06.490598
    Journal:
    E-pub date: 1 Aug 2022
    Authors: S Wagner, D Brierley, A Leeson-Payne, W Jiang, R Chianese, B Lam, G Dowsett, C Cristiano, D Lyons, F Reimann, F Gribble, GSH Yeo, S Trapp, L Heisler

    Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice – Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells.

    DOI: http://doi.org/10.1016/j.molmet.2019.09.001
    Journal: Mol Metab
    E-pub date: 1 Nov 2019
    Authors: LJ Billing, P Larraufie, J Lewis, A Leiter, J Li, B Lam, GS Yeo, DA Goldspink, RG Kay, FM Gribble, F Reimann

    Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling.

    DOI: http://doi.org/10.2337/db18-0883
    Journal: Diabetes
    E-pub date: 1 May 2019
    Authors: GP Roberts, P Larraufie, P Richards, RG Kay, SG Galvin, EL Miedzybrodzka, A Leiter, HJ Li, LL Glass, MKL Ma, B Lam, GSH Yeo, R Scharfmann, D Chiarugi, RH Hardwick, F Reimann, FM Gribble

    Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.

    DOI: http://doi.org/10.1038/s41467-019-09045-9
    Journal: Nat Commun
    E-pub date: 4 Mar 2019
    Authors: VB Lu, J Rievaj, EA O'Flaherty, CA Smith, R Pais, LA Pattison, G Tolhurst, AB Leiter, DC Bulmer, FM Gribble, F Reimann

    A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium.

    DOI: http://doi.org/10.1210/en.2015-1301
    Journal: Endocrinology
    E-pub date: 1 Nov 2015
    Authors: A Adriaenssens, BYH Lam, L Billing, K Skeffington, S Sewing, F Reimann, F Gribble