Kristian Franze

University Position

Professor

Interests

We are taking an interdisciplinary approach to investigate how cellular forces, local cell and tissue stiffness and cellular mechanosensitivity contribute to CNS development and disease. Methods we are exploiting include atomic force microscopy, traction force microscopy, custom-built simple and complex compliant cell culture substrates, optogenetics and cell biological techniques.

Key Publications

Mutation of the ALS/FTD-associated RNA-binding protein FUS affects axonal development.

DOI: http://doi.org/10.1523/JNEUROSCI.2148-23.2024
Journal: J Neurosci
E-pub date: 3 Jul 2024
Authors: FWV Tartwijk, LCS Wunderlich, I Mela, S Makarchuk, MAH Jakobs, S Qamar, K Franze, GSK Schierle, PHS George-Hyslop, JQ Lin, CE Holt, CF Kaminski

Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons.

DOI: http://doi.org/10.1016/j.cell.2018.11.030
Journal: Cell
E-pub date: 10 Jan 2019
Authors: J-M Cioni, JQ Lin, AV Holtermann, M Koppers, MAH Jakobs, A Azizi, B Turner-Bridger, T Shigeoka, K Franze, WA Harris, CE Holt