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EMAIL fwv21@cam.ac.uk
College Queens' College
Department
  • Chemical Engineering and Biotechnology
    • School
  • Technology
    • Research Theme Lifelong Brain Development and Brain Ageing Neurons, Circuits and Networks
    Research Focus

    Keywords

  • Axon
  • Actin
  • Aggregate-Prone Proteins
  • Amyotrophic Lateral Sclerosis
  • Asymmetry
  • Atomic Force Microscopy
  • Axon & Neuronal Degeneration
  • Axonal Branching
  • Axonal Protein Synthesis
  • Axonal Transport
  • Biophysics
  • Cell Biology
  • Cell Mechanics
  • Compartmentalisation
  • Dendrites
  • Diffusion
  • Endoplasmic Reticulum
  • Eukaryotic Cells
  • Fluorescence Lifetime Imaging
  • Fluorescence Microscopy
  • FRET
  • Frontotemporal Dementia
  • Heterogeneity
  • Image Analysis
  • Live Cell Imaging
  • Local Protein Synthesis
  • Local Translation
  • Microdomain
  • Molecular Biology
  • mRNA
  • Neurodegeneration
  • Neurodevelopment
  • Protein Phase Separation
  • Retinal Ganglion Cells
  • RNA Binding Proteins
  • RNA Localisation
  • RNP Granules
  • Superresolution Microscopy
  • Xenopus Laevis

    • Clinical Conditions

  • Frontotemporal dementia
  • Motor neurone disease

    • Equipment & Techniques

  • Fluorescence microscopy

    • Science Culture

  • Teaching
  • Public Outreach

    • Back

    Dr Francesca van Tartwijk

    (she/her/hers)
    University Position
    Research Associate

    Interests

    My research focusses on the formation and properties of specialised subcellular compartments. During my PhD, I investigated the effects of the ALS/FTD-associated RNA-binding protein FUS on axonal branching and organisation. My current postdoctoral research centres on macromolecular crowding and local heterogeneity in the cytosol.

    The axonal cytoskeleton during development

    The actin (green) and microtubule (yellow) cytoskeleton of extending retinal ganglion cells

    Key Publications

    Mutation of the ALS/FTD-associated RNA-binding protein FUS affects axonal development.

    DOI: http://doi.org/10.1523/JNEUROSCI.2148-23.2024
    Journal: J Neurosci
    E-pub date: 3 Jul 2024
    Authors: FWV Tartwijk, LCS Wunderlich, I Mela, S Makarchuk, MAH Jakobs, S Qamar, K Franze, GSK Schierle, PHS George-Hyslop, JQ Lin, CE Holt, CF Kaminski

    Protein Condensation, Cellular Organization, and Spatiotemporal Regulation of Cytoplasmic Properties.

    DOI: http://doi.org/10.1002/adbi.202101328
    Journal: Adv Biol (Weinh)
    E-pub date: 1 Nov 2022
    Authors: FW van Tartwijk, CF Kaminski

    Axonal mRNA translation in neurological disorders.

    DOI: http://doi.org/10.1080/15476286.2020.1822638
    Journal: RNA Biol
    E-pub date: 1 Jul 2021
    Authors: JQ Lin, FW van Tartwijk, CE Holt

    The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes.

    DOI: http://doi.org/10.1126/sciadv.abc7209
    Journal: Sci Adv
    E-pub date: 1 Dec 2020
    Authors: M Lu, FW van Tartwijk, JQ Lin, W Nijenhuis, P Parutto, M Fantham, CN Christensen, E Avezov, CE Holt, A Tunnacliffe, D Holcman, L Kapitein, GSK Schierle, CF Kaminski

    Publications

    Advances in the study of organelle interactions and their role in neurodegenerative diseases enabled by super-resolution microscopy.

    DOI: http://doi.org/10.1016/j.nbd.2021.105475
    Journal: Neurobiol Dis
    E-pub date: 1 Nov 2021
    Authors: M Lu, E Ward, FW van Tartwijk, CF Kaminski

    Inflammatory neuronal loss in the substantia nigra induced by systemic lipopolysaccharide is prevented by knockout of the P2Y6 receptor in mice.

    DOI: http://doi.org/10.1186/s12974-021-02280-2
    Journal: J Neuroinflammation
    E-pub date: 11 Oct 2021
    Authors: S Milde, FW van Tartwijk, A Vilalta, TC Hornik, JM Dundee, M Puigdellívol, GC Brown

    A waveguide imaging platform for live-cell TIRF imaging of neurons over large fields of view.

    DOI: http://doi.org/10.1002/jbio.201960222
    Journal: J Biophotonics
    E-pub date: 1 Jun 2020
    Authors: IS Opstad, F Ströhl, M Fantham, C Hockings, O Vanderpoorten, FW van Tartwijk, JQ Lin, J-C Tinguely, FT Dullo, GS Kaminski-Schierle, BS Ahluwalia, CF Kaminski

    The structure and global distribution of the endoplasmic reticulum network is actively regulated by lysosomes

    DOI: http://doi.org/10.1101/2020.01.15.907444
    Journal:
    E-pub date: 15 Jan 2020
    Authors: M Lu, FW van Tartwijk, JQ Lin, W Nijenhuis, P Parutto, M Fantham, CN Christensen, E Avezov, CE Holt, A Tunnacliffe, D Holcman, LC Kapitein, GK Schierle, CF Kaminski

    A protocol for single-molecule translation imaging in xenopus retinal ganglion cells

    DOI: http://doi.org/10.1007/978-1-0716-0532-5_14
    Journal:
    E-pub date: 1 Jan 2020
    Authors: F Ströhl, JQ Lin, FW van Tartwijk, HHW Wong, CE Holt, CF Kaminski

    On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons.

    DOI: http://doi.org/10.1016/j.celrep.2019.11.025
    Journal: Cell Rep
    E-pub date: 10 Dec 2019
    Authors: T Shigeoka, M Koppers, HH-W Wong, JQ Lin, R Cagnetta, A Dwivedy, J de Freitas Nascimento, FW van Tartwijk, F Ströhl, J-M Cioni, J Schaeffer, M Carrington, CF Kaminski, H Jung, WA Harris, CE Holt