College Queens' College
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  • Axon
  • Actin
  • Aggregate-Prone Proteins
  • Amyotrophic Lateral Sclerosis
  • Asymmetry
  • Atomic Force Microscopy
  • Axon & Neuronal Degeneration
  • Axonal Branching
  • Axonal Protein Synthesis
  • Axonal Transport
  • Biophysics
  • Cell Biology
  • Cell Mechanics
  • Compartmentalisation
  • Dendrites
  • Diffusion
  • Endoplasmic Reticulum
  • Eukaryotic Cells
  • Fluorescence Lifetime Imaging
  • Fluorescence Microscopy
  • FRET
  • Frontotemporal Dementia
  • Heterogeneity
  • Image Analysis
  • Live Cell Imaging
  • Local Protein Synthesis
  • Local Translation
  • Microdomain
  • Molecular Biology
  • mRNA
  • Neurodegeneration
  • Neurodevelopment
  • Protein Phase Separation
  • Retinal Ganglion Cells
  • RNA Binding Proteins
  • RNA Localisation
  • RNP Granules
  • Superresolution Microscopy
  • Xenopus Laevis
  • Clinical Conditions

  • Frontotemporal dementia
  • Motor neurone disease
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  • Fluorescence microscopy
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    Dr Francesca van Tartwijk

    University Position
    Research Associate


    My research focusses on the formation and properties of specialised subcellular compartments. During my PhD, I investigated the effects of the ALS/FTD-associated RNA-binding protein FUS on axonal branching and organisation. My current postdoctoral research centres on macromolecular crowding and local heterogeneity in the cytosol.

    The axonal cytoskeleton during development

    The actin (green) and microtubule (yellow) cytoskeleton of extending retinal ganglion cells

    Key Publications

    Protein Condensation, Cellular Organization, and Spatiotemporal Regulation of Cytoplasmic Properties.

    Journal: Adv Biol (Weinh)
    E-pub date: 1 Nov 2022
    Authors: FW van Tartwijk, CF Kaminski

    Axonal mRNA translation in neurological disorders.

    Journal: RNA Biol
    E-pub date: 1 Jul 2021
    Authors: JQ Lin, FW van Tartwijk, CE Holt


    Mutation of the ALS/FTD-associated RNA-binding protein FUS alters axonal cytoskeletal organisation

    E-pub date: 1 Aug 2022
    Authors: F van Tartwijk, LCS Wunderlich, I Mela, S Makarchuk, MAH Jakobs, S Qamar, K Franze, GK Schierle, P St George-Hyslop, JQ Lin, C Holt, C Kaminski

    Inflammatory neuronal loss in the substantia nigra induced by systemic lipopolysaccharide is prevented by knockout of the P2Y6 receptor in mice.

    Journal: J Neuroinflammation
    E-pub date: 11 Oct 2021
    Authors: S Milde, FW van Tartwijk, A Vilalta, TC Hornik, JM Dundee, M Puigdellívol, GC Brown

    The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes.

    Journal: Sci Adv
    E-pub date: 1 Dec 2020
    Authors: M Lu, FW van Tartwijk, JQ Lin, W Nijenhuis, P Parutto, M Fantham, CN Christensen, E Avezov, CE Holt, A Tunnacliffe, D Holcman, L Kapitein, GSK Schierle, CF Kaminski

    A waveguide imaging platform for live-cell TIRF imaging of neurons over large fields of view.

    Journal: J Biophotonics
    E-pub date: 1 Jun 2020
    Authors: IS Opstad, F Ströhl, M Fantham, C Hockings, O Vanderpoorten, FW van Tartwijk, JQ Lin, J-C Tinguely, FT Dullo, GS Kaminski-Schierle, BS Ahluwalia, CF Kaminski

    A protocol for single-molecule translation imaging in xenopus retinal ganglion cells

    E-pub date: 1 Jan 2020
    Authors: F Ströhl, JQ Lin, FW van Tartwijk, HHW Wong, CE Holt, CF Kaminski

    On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons.

    Journal: Cell Rep
    E-pub date: 10 Dec 2019
    Authors: T Shigeoka, M Koppers, HH-W Wong, JQ Lin, R Cagnetta, A Dwivedy, J de Freitas Nascimento, FW van Tartwijk, F Ströhl, J-M Cioni, J Schaeffer, M Carrington, CF Kaminski, H Jung, WA Harris, CE Holt