Department

Institute

Wellcome – MRC Institute of Metabolic Science

Research Theme Neurons, Circuits and Networks Beyond the Neuron

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Professor Giles Yeo MBE

University Position

Professor

Interests

I study brain control of body-weight, and currently have two main aims: Identifying new players in the hypothalamic control of energy balance. a. Genetic studies point to the brain as having a crucial role in modulating appetitive behaviour. A collaboration with the Cambridge Brain Bank allowing us access to human donor brain samples, coupled with ?dropseq? single-cell sequencing technologies and single-molecule FISH, provides us an opportunity to map the functional architecture of the human hypothalamus underlying appetitive behaviour. b. Understanding the physiological role of known genetic modifiers influencing food intake and body-weight. Drosophila has been demonstrated to be an excellent in vivo model for dissecting metabolic homeostasis pathways. We have developed a suite of assays to examine changes in the state of energy homeostasis and food intake. We are also currently interested the role of the non-coding RNAs Snord116 in the aetiology of Prader-Willi Syndrome (PWS).

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Key Publications

A program of successive gene expression in mouse one-cell embryos.

DOI: http://doi.org/10.1016/j.celrep.2023.112023
Journal: Cell Rep
E-pub date: 28 Feb 2023
Authors: M Asami, BYH Lam, M Hoffmann, T Suzuki, X Lu, N Yoshida, MK Ma, K Rainbow, M Gužvić, MD VerMilyea, GSH Yeo, CA Klein, ACF Perry

HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus.

DOI: http://doi.org/10.1038/s42255-022-00657-y
Journal: Nat Metab
E-pub date: 1 Oct 2022
Authors: L Steuernagel, BYH Lam, P Klemm, GKC Dowsett, CA Bauder, JA Tadross, TS Hitschfeld, A Del Rio Martin, W Chen, AJ de Solis, H Fenselau, P Davidsen, I Cimino, SN Kohnke, D Rimmington, AP Coll, A Beyer, GSH Yeo, JC Brüning

Human embryonic genome activation initiates at the one-cell stage.

DOI: http://doi.org/10.1016/j.stem.2021.11.012
Journal: Cell Stem Cell
E-pub date: 3 Feb 2022
Authors: M Asami, BYH Lam, MK Ma, K Rainbow, S Braun, MD VerMilyea, GSH Yeo, ACF Perry

A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing.

DOI: http://doi.org/10.1016/j.molmet.2021.101240
Journal: Mol Metab
E-pub date: 1 Nov 2021
Authors: GKC Dowsett, BYH Lam, JA Tadross, I Cimino, D Rimmington, AP Coll, J Polex-Wolf, LB Knudsen, C Pyke, GSH Yeo

MC3R links nutritional state to childhood growth and the timing of puberty.

DOI: http://doi.org/10.1038/s41586-021-04088-9
Journal: Nature
E-pub date: 1 Nov 2021
Authors: BYH Lam, A Williamson, S Finer, FR Day, JA Tadross, A Gonçalves Soares, K Wade, P Sweeney, MN Bedenbaugh, DT Porter, A Melvin, KLJ Ellacott, RN Lippert, S Buller, J Rosmaninho-Salgado, GKC Dowsett, KE Ridley, Z Xu, I Cimino, D Rimmington, K Rainbow, K Duckett, S Holmqvist, A Khan, X Dai, EG Bochukova, Genes & Health Research Team, RC Trembath, HC Martin, AP Coll, DH Rowitch, NJ Wareham, DA van Heel, N Timpson, RB Simerly, KK Ong, RD Cone, C Langenberg, JRB Perry, GS Yeo, S O'Rahilly

Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort.

DOI: http://doi.org/10.1038/s41591-021-01349-y
Journal: Nat Med
E-pub date: 1 Jun 2021
Authors: KH Wade, BYH Lam, A Melvin, W Pan, LJ Corbin, DA Hughes, K Rainbow, J-H Chen, K Duckett, X Liu, J Mokrosiński, A Mörseburg, S Neaves, A Williamson, C Zhang, IS Farooqi, GSH Yeo, NJ Timpson, S O'Rahilly

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.

DOI: http://doi.org/10.1007/s00125-016-4033-1
Journal: Diabetologia
E-pub date: 1 Oct 2016
Authors: AE Adriaenssens, B Svendsen, BYH Lam, GSH Yeo, JJ Holst, F Reimann, FM Gribble

Publications

Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice.

DOI: http://doi.org/10.1038/s41467-023-38618-y
Journal: Nat Commun
E-pub date: 29 May 2023
Authors: JM Ramos-Pittol, I Fernandes-Freitas, A Milona, SM Manchishi, K Rainbow, BYH Lam, JA Tadross, A Beucher, WH Colledge, I Cebola, KG Murphy, I Miguel-Aliaga, GSH Yeo, WS Dhillo, BM Owen

The initiation of mammalian embryonic transcription: to begin at the beginning.

DOI: http://doi.org/10.1016/j.tcb.2022.08.008
Journal: Trends Cell Biol
E-pub date: 1 May 2023
Authors: ACF Perry, M Asami, BYH Lam, GSH Yeo

New molecular techniques for exploring neuronal appetite pathways

DOI: http://doi.org/10.1016/j.coemr.2021.100309
Journal: Current Opinion in Endocrine and Metabolic Research
E-pub date: 1 Feb 2022
Authors: JA Tadross, BYH Lam, GSH Yeo

The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth.

DOI: http://doi.org/10.1016/j.devcel.2021.12.005
Journal: Dev Cell
E-pub date: 10 Jan 2022
Authors: I Sandovici, A Georgopoulou, V Pérez-García, A Hufnagel, J López-Tello, BYH Lam, SN Schiefer, C Gaudreau, F Santos, K Hoelle, GSH Yeo, K Burling, M Reiterer, AL Fowden, GJ Burton, CM Branco, AN Sferruzzi-Perri, M Constância

High Coexpression of the Ghrelin and LEAP2 Receptor GHSR With Pancreatic Polypeptide in Mouse and Human Islets.

DOI: http://doi.org/10.1210/endocr/bqab148
Journal: Endocrinology
E-pub date: 1 Oct 2021
Authors: D Gupta, GKC Dowsett, BK Mani, K Shankar, S Osborne-Lawrence, NP Metzger, BYH Lam, GSH Yeo, JM Zigman

Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence.

DOI: http://doi.org/10.1016/j.celrep.2021.109362
Journal: Cell Rep
E-pub date: 13 Jul 2021
Authors: S Kohnke, S Buller, D Nuzzaci, K Ridley, B Lam, H Pivonkova, MA Bentsen, KM Alonge, C Zhao, J Tadross, S Holmqvist, T Shimizu, H Hathaway, H Li, W Macklin, MW Schwartz, WD Richardson, GSH Yeo, RJM Franklin, RT Karadottir, DH Rowitch, C Blouet

Neurochemical Characterization of Brainstem Pro-Opiomelanocortin Cells.

DOI: http://doi.org/10.1210/endocr/bqaa032
Journal: Endocrinology
E-pub date: 1 Apr 2020
Authors: T Georgescu, D Lyons, B Doslikova, AP Garcia, O Marston, LK Burke, R Chianese, BYH Lam, GSH Yeo, JJ Rochford, AS Garfield, LK Heisler

Transcriptional signature of prion-induced neurotoxicity in a Drosophila model of transmissible mammalian prion disease

DOI: http://doi.org/10.1042/BCJ20190872
Journal: Biochemical Journal
E-pub date: 28 Feb 2020
Authors: A Thackray, B Lam, A Shahira Binti Ab Razak, G Yeo, R Bujdoso

Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice – Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells.

DOI: http://doi.org/10.1016/j.molmet.2019.09.001
Journal: Mol Metab
E-pub date: 1 Nov 2019
Authors: LJ Billing, P Larraufie, J Lewis, A Leiter, J Li, B Lam, GS Yeo, DA Goldspink, RG Kay, FM Gribble, F Reimann

Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling.

DOI: http://doi.org/10.2337/db18-0883
Journal: Diabetes
E-pub date: 1 May 2019
Authors: GP Roberts, P Larraufie, P Richards, RG Kay, SG Galvin, EL Miedzybrodzka, A Leiter, HJ Li, LL Glass, MKL Ma, B Lam, GSH Yeo, R Scharfmann, D Chiarugi, RH Hardwick, F Reimann, FM Gribble

Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome.

DOI: http://doi.org/10.1172/JCI97007
Journal: J Clin Invest
E-pub date: 1 Mar 2018
Authors: J Polex-Wolf, BY Lam, R Larder, J Tadross, D Rimmington, F Bosch, VJ Cenzano, E Ayuso, MK Ma, K Rainbow, AP Coll, S O'Rahilly, GS Yeo

Selective rab11 transport and the intrinsic regenerative ability of CNS axons.

DOI: http://doi.org/10.7554/eLife.26956
Journal: Elife
E-pub date: 8 Aug 2017
Authors: H Koseki, M Donegá, BY Lam, V Petrova, S van Erp, GS Yeo, JC Kwok, C Ffrench-Constant, R Eva, JW Fawcett

Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity.

DOI: http://doi.org/10.1016/j.cell.2015.12.025
Journal: Cell
E-pub date: 28 Jan 2016
Authors: K Dalgaard, K Landgraf, S Heyne, A Lempradl, J Longinotto, K Gossens, M Ruf, M Orthofer, R Strogantsev, M Selvaraj, TT-H Lu, E Casas, R Teperino, MA Surani, I Zvetkova, D Rimmington, YCL Tung, B Lam, R Larder, GSH Yeo, S O'Rahilly, T Vavouri, E Whitelaw, JM Penninger, T Jenuwein, C-L Cheung, AC Ferguson-Smith, AP Coll, A Körner, JA Pospisilik

Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm.

DOI: http://doi.org/10.1042/BSR20140111
Journal: Biosci Rep
E-pub date: 22 Oct 2014
Authors: P Gulati, E Avezov, M Ma, R Antrobus, P Lehner, S O'Rahilly, GSH Yeo

DEFLATE compression algorithm corrects for overestimation of phylogenetic diversity by Grantham approach to single-nucleotide polymorphism classification.

DOI: http://doi.org/10.3390/ijms15058491
Journal: Int J Mol Sci
E-pub date: 13 May 2014
Authors: A Schlosberg, BYH Lam, GSH Yeo, RJ Clifton-Bligh