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Clinical Conditions
Equipment & Techniques
Science Culture
We are focused upon understanding the properties and functioning of the key neural populations controlling fertility in mammals; the gonadotropin-releasing hormone (GnRH) neurons and the kisspeptin neurons. Together, these cells generate the "pulse" and "surge" patterns of hormone secretion that are responsible for the initiation of puberty and the subsequent maintenance of reproductive function in adult males and females. Studies are undertaken in a variety of genetically-modified mouse models using tissue clearing and expansion microscopy, single cell electrophysiology and calcium imaging in acute brain slices in vitro, RNAseq gene profiling, in vivo GCaMP imaging of the activity of selected neurons and neural populations in freely-behaving mice, and in vivo CRISPR-based gene editing.
