EMAIL hfc23@cam.ac.uk

Department

Physiology, Development and Neuroscience

School

Biological Sciences

Institute

Behavioural and Clinical Neuroscience Institute

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Research Theme Neurons, Circuits and Networks Adaptive Brain Computations Lifelong Brain Development and Brain Ageing

Research Focus

Keywords

Neurochemistry

Cognition

Neurocognition

Behaviour

Animal Models

Clinical Conditions

Anxiety disorders

Depressive disorders

Schizophrenia

Other

Equipment & Techniques

Behavioural analysis

Magnetic resonance imaging (MRI)

Positron Emission Tomography (PET)

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Dr Hannah Clarke PhD

University Position

Associate Professor

Dr Hannah Clarke is pleased to consider applications from prospective PhD students.

Interests

Understanding the neural and neurochemical basis of behaviours mediated by the prefrontal cortex and their relevance to psychiatric disorders.

Key Publications

Differential Effects of the Inactivation of Anterior and Posterior Orbitofrontal Cortex on Affective Responses to Proximal and Distal Threat, and Reward Anticipation in the Common Marmoset.

DOI: http://doi.org/10.1093/cercor/bhab240
Journal: Cereb Cortex
E-pub date: 30 Mar 2022
Authors: ZM Stawicka, R Massoudi, L Oikonomidis, L McIver, K Mulvihill, SKL Quah, GJ Cockcroft, HF Clarke, NK Horst, CM Wood, AC Roberts

Glutamate Within the Marmoset Anterior Hippocampus Interacts with Area 25 to Regulate the Behavioral and Cardiovascular Correlates of High-Trait Anxiety.

DOI: http://doi.org/10.1523/JNEUROSCI.2451-18.2018
Journal: J Neurosci
E-pub date: 17 Apr 2019
Authors: JL Zeredo, SKL Quah, CU Wallis, L Alexander, GJ Cockcroft, AM Santangelo, J Xia, Y Shiba, JW Dalley, RN Cardinal, AC Roberts, HF Clarke

Opposing roles of primate areas 25 and 32 and their putative rodent homologs in the regulation of negative emotion.

DOI: http://doi.org/10.1073/pnas.1620115114
Journal: Proc Natl Acad Sci U S A
E-pub date: 16 May 2017
Authors: CU Wallis, RN Cardinal, L Alexander, AC Roberts, HF Clarke

Regional inactivations of primate ventral prefrontal cortex reveal two distinct mechanisms underlying negative bias in decision making.

DOI: http://doi.org/10.1073/pnas.1422440112
Journal: Proc Natl Acad Sci U S A
E-pub date: 31 Mar 2015
Authors: HF Clarke, NK Horst, AC Roberts

Cognitive inflexibility after prefrontal serotonin depletion.

DOI: http://doi.org/10.1126/science.1094987
Journal: Science
E-pub date: 7 May 2004
Authors: HF Clarke, JW Dalley, HS Crofts, TW Robbins, AC Roberts

Publications

Differential Contribution of Anterior and Posterior Midcingulate Subregions to Distal and Proximal Threat Reactivity in Marmosets.

DOI: http://doi.org/10.1093/cercor/bhab121
Journal: Cereb Cortex
E-pub date: 26 Aug 2021
Authors: SS Rahman, K Mulvihill, CM Wood, SKL Quah, NK Horst, HF Clarke, GJ Cockcroft, AM Santangelo, AC Roberts

Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat.

DOI: http://doi.org/10.1038/s41467-020-19167-0
Journal: Nat Commun
E-pub date: 26 Oct 2020
Authors: L Alexander, CM Wood, PLR Gaskin, SJ Sawiak, TD Fryer, YT Hong, L McIver, HF Clarke, AC Roberts

Why we need nonhuman primates to study the role of ventromedial prefrontal cortex in the regulation of threat- and reward-elicited responses.

DOI: http://doi.org/10.1073/pnas.1902288116
Journal: Proc Natl Acad Sci U S A
E-pub date: 26 Dec 2019
Authors: AC Roberts, HF Clarke

Hippocampal Interaction With Area 25, but not Area 32, Regulates Marmoset Approach-Avoidance Behavior.

DOI: http://doi.org/10.1093/cercor/bhz015
Journal: Cereb Cortex
E-pub date: 17 Dec 2019
Authors: CU Wallis, GJ Cockcroft, RN Cardinal, AC Roberts, HF Clarke

Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.

DOI: http://doi.org/10.1073/pnas.1902087116
Journal: Proc Natl Acad Sci U S A
E-pub date: 16 Jul 2019
Authors: AM Santangelo, SJ Sawiak, T Fryer, Y Hong, Y Shiba, HF Clarke, PJ Riss, V Ferrari, R Tait, J Suckling, FI Aigbirhio, AC Roberts

A Focus on the Functions of Area 25.

DOI: http://doi.org/10.3390/brainsci9060129
Journal: Brain Sci
E-pub date: 3 Jun 2019
Authors: L Alexander, HF Clarke, AC Roberts

Fractionating Blunted Reward Processing Characteristic of Anhedonia by Over-Activating Primate Subgenual Anterior Cingulate Cortex.

DOI: http://doi.org/10.1016/j.neuron.2018.11.021
Journal: Neuron
E-pub date: 16 Jan 2019
Authors: L Alexander, PLR Gaskin, SJ Sawiak, TD Fryer, YT Hong, GJ Cockcroft, HF Clarke, AC Roberts

Novel Primate Model of Serotonin Transporter Genetic Polymorphisms Associated with Gene Expression, Anxiety and Sensitivity to Antidepressants.

DOI: http://doi.org/10.1038/npp.2016.41
Journal: Neuropsychopharmacology
E-pub date: 31 Aug 2016
Authors: AM Santangelo, M Ito, Y Shiba, HF Clarke, EH Schut, G Cockcroft, AC Ferguson-Smith, AC Roberts

Novel Primate Model of Serotonin Transporter Genetic Polymorphisms Associated with Gene Expression, Anxiety and Sensitivity to Antidepressants

DOI: http://doi.org/10.1038/npp.2016.41;
Journal: Neuropsychopharmacology
E-pub date: 21 Mar 2016
Authors: AM Santangelo, M Ito, Y Shiba, HF Clarke, EHS Schut, G Cockcroft, AC Ferguson-Smith, AC Roberts

Role of Central Serotonin in Anticipation of Rewarding and Punishing Outcomes: Effects of Selective Amygdala or Orbitofrontal 5-HT Depletion.

DOI: http://doi.org/10.1093/cercor/bhu102
Journal: Cereb Cortex
E-pub date: 1 Sep 2015
Authors: R Rygula, HF Clarke, RN Cardinal, GJ Cockcroft, J Xia, JW Dalley, TW Robbins, AC Roberts

Serotonergic, brain volume and attentional correlates of trait anxiety in primates.

DOI: http://doi.org/10.1038/npp.2014.324
Journal: Neuropsychopharmacology
E-pub date: 1 May 2015
Authors: Y Mikheenko, Y Shiba, S Sawiak, K Braesicke, G Cockcroft, H Clarke, AC Roberts

Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity.

DOI: http://doi.org/10.1523/JNEUROSCI.0718-14.2014
Journal: J Neurosci
E-pub date: 28 May 2014
Authors: HF Clarke, RN Cardinal, R Rygula, YT Hong, TD Fryer, SJ Sawiak, V Ferrari, G Cockcroft, FI Aigbirhio, TW Robbins, AC Roberts

Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion.

DOI: http://doi.org/10.1016/j.biopsych.2012.03.007
Journal: Biological Psychiatry
E-pub date: 15 Aug 2012
Authors: C Agustín-Pavón, K Braesicke, Y Shiba, AM Santangelo, Y Mikheenko, G Cockroft, F Asma, H Clarke, M-S Man, AC Roberts

Reversal learning in fronto-striatal circuits: A functional, autonomic, and neurochemical analysis

DOI: http://doi.org/10.1093/acprof:oso/9780199600434.003.0010
Journal:
E-pub date: 1 May 2011
Authors: HF Clarke, AC Roberts

Dopamine, but not serotonin, regulates reversal learning in the marmoset caudate nucleus.

DOI: http://doi.org/10.1523/JNEUROSCI.5066-10.2011
Journal: J Neurosci
E-pub date: 16 Mar 2011
Authors: HF Clarke, GJ Hill, TW Robbins, AC Roberts

Differential contributions of the primate ventrolateral prefrontal and orbitofrontal cortex to serial reversal learning.

DOI: http://doi.org/10.1523/JNEUROSCI.2631-10.2010
Journal: J Neurosci
E-pub date: 27 Oct 2010
Authors: R Rygula, SC Walker, HF Clarke, TW Robbins, AC Roberts

The role of the orbitofrontal cortex and medial striatum in the regulation of prepotent responses to food rewards.

DOI: http://doi.org/10.1093/cercor/bhn137
Journal: Cereb Cortex
E-pub date: 1 Apr 2009
Authors: MS Man, HF Clarke, AC Roberts

Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex.

DOI: http://doi.org/10.1523/JNEUROSCI.1521-08.2008
Journal: J Neurosci
E-pub date: 22 Oct 2008
Authors: HF Clarke, TW Robbins, AC Roberts