• Zoology
  • Research Focus


  • Synaptic Function
  • Ligand-Gated Ion Channel
  • Equipment & Techniques

  • Behavioural analysis
  • Electrophysiological recording techniques
  • Confocal microscopy
  • Back

    Dr Iris Hardege

    University Position
    Royal Society University Research Fellow
    Dr Iris Hardege is pleased to consider applications from prospective PhD students.


    The basics of neural communication is conserved across species, with neurotransmitters acting as messengers across synapses. My work focusses on the receptors for these neurotransmitters and understanding their diversity and function with the nervous system of the model organism C. elegans. The nematode C. elegans is a powerful model organism, having a small and completely mapped nervous system and genome, allowing us to probe the detailed mechanisms of these receptors within a whole organism. I am particularly interested in ion channel receptors and understanding the way in which their balance at the synapses effects circuits and learning.

    Key Publications

    A Novel and Functionally Diverse Class of Acetylcholine-gated Ion Channels

    E-pub date: 1 Aug 2021
    Authors: I Hardege, J Morud, A Courtney, W Schafer

    Neuronally Produced Betaine Acts via a Novel Ligand Gated Ion Channel to Control Behavioural States

    E-pub date: 1 Aug 2021
    Authors: I Hardege, J Morud, J Yu, TS Wilson, FC Schroeder, WR Schafer

    Deorphanisation of novel biogenic amine-gated ion channels identifies a new serotonin receptor for learning

    E-pub date: 1 Aug 2020
    Authors: J Morud, I Hardege, H Liu, T Wu, S Basu, Y Zhang, W Schafer


    Neuropeptide signalling shapes feeding and reproductive behaviours in male C. elegans

    E-pub date: 1 Aug 2021
    Authors: M Gadenne, I Hardege, D Suleski, P Jaggers, I Beets, W Schafer, YL Chew

    Distinct roles for two Caenorhabditis elegans acid-sensing ion channels in an ultradian clock

    E-pub date: 1 Aug 2021
    Authors: E Kaulich, B Ackley, Y-Q Tang, I Hardege, W Schafer, D Walker

    Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPRER Activation and Behavior in C. elegans.

    Journal: Dev Cell
    E-pub date: 21 Dec 2020
    Authors: NP Özbey, S Imanikia, C Krueger, I Hardege, J Morud, M Sheng, WR Schafer, MO Casanueva, RC Taylor

    Functional characterization of common BCL11B gene desert variants suggests a lymphocyte-mediated association of BCL11B with aortic stiffness.

    Journal: Eur J Hum Genet
    E-pub date: 1 Nov 2018
    Authors: RA Maskari, I Hardege, S Cleary, N Figg, Y Li, K Siew, A Khir, Y Yu, P Liu, I Wilkinson, K O'Shaughnessy, Yasmin

    Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels.

    Journal: Clin Sci (Lond)
    E-pub date: 16 Jan 2018
    Authors: I Hardege, L Long, R Al Maskari, N Figg, KM O'Shaughnessy

    Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.

    Journal: EMBO Mol Med
    E-pub date: 1 Oct 2015
    Authors: F-R Schumacher, K Siew, J Zhang, C Johnson, N Wood, SE Cleary, RS Al Maskari, JT Ferryman, I Hardege, Yasmin, NL Figg, R Enchev, A Knebel, KM O'Shaughnessy, T Kurz

    Novel Insertion Mutation in KCNJ5 Channel Produces Constitutive Aldosterone Release From H295R Cells.

    Journal: Mol Endocrinol
    E-pub date: 1 Oct 2015
    Authors: I Hardege, S Xu, RD Gordon, AJ Thompson, N Figg, M Stowasser, R Murrell-Lagnado, KM O'Shaughnessy

    A conserved domain targets exported PHISTb family proteins to the periphery of Plasmodium infected erythrocytes.

    Journal: Mol Biochem Parasitol
    E-pub date: 31 Aug 2014
    Authors: SJ Tarr, RW Moon, I Hardege, AR Osborne