Professor Peter St George-Hyslop FRS

University Position

Professor
Emeritus Professor
Visiting Scientist

Interests

My laboratory focuses upon understanding the causes and molecular mechanisms of neurodegenerative diseases such as Alzheimer's Disease, Parkinson's Disease and Fronto-Temporal Dementia. We and others have shown that these diseases are frequently caused by the accumulation neurotoxic proteins or protein fragments. We employ genetic, molecular biological, cell biological, and animal modeling strategies to: 1) identify disease-causing genes; and 2) to identify the molecular pathways by which these mutation or polymorphisms lead to neuronal death.

Key Publications

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes

DOI: http://doi.org/10.1038/s41467-025-58142-5
Journal: Nat Commun
E-pub date: 21 Mar 2025
Authors: J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, G Šneiderienė, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop

Mutation of the ALS/FTD-associated RNA-binding protein FUS affects axonal development.

DOI: http://doi.org/10.1523/JNEUROSCI.2148-23.2024
Journal: J Neurosci
E-pub date: 3 Jul 2024
Authors: FWV Tartwijk, LCS Wunderlich, I Mela, S Makarchuk, MAH Jakobs, S Qamar, K Franze, GSK Schierle, PHS George-Hyslop, JQ Lin, CE Holt, CF Kaminski

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.

DOI: http://doi.org/10.1016/j.cell.2019.08.050
Journal: Cell
E-pub date: 19 Sep 2019
Authors: Y-C Liao, MS Fernandopulle, G Wang, H Choi, L Hao, CM Drerup, R Patel, S Qamar, J Nixon-Abell, Y Shen, W Meadows, M Vendruscolo, TPJ Knowles, M Nelson, MA Czekalska, G Musteikyte, MA Gachechiladze, CA Stephens, HA Pasolli, LR Forrest, P St George-Hyslop, J Lippincott-Schwartz, ME Ward

Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1

DOI: http://doi.org/10.1016/j.cell.2018.03.056
Journal: Cell
E-pub date: 19 Apr 2018
Authors: PH St George-Hyslop, S Qamar, G Wang, SJ Randle, FS Ruggeri, J Varela, CF Kaminski, GS Kaminski, M Vendruscolo, TPJ Knowles, D Klenerman, CE Holt, Q Lin, W meadows

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function.

DOI: http://doi.org/10.1016/j.neuron.2015.10.030
Journal: Neuron
E-pub date: 18 Nov 2015
Authors: T Murakami, S Qamar, JQ Lin, GSK Schierle, E Rees, A Miyashita, AR Costa, RB Dodd, FTS Chan, CH Michel, D Kronenberg-Versteeg, Y Li, S-P Yang, Y Wakutani, W Meadows, RR Ferry, L Dong, GG Tartaglia, G Favrin, W-L Lin, DW Dickson, M Zhen, D Ron, G Schmitt-Ulms, PE Fraser, NA Shneider, C Holt, M Vendruscolo, CF Kaminski, P St George-Hyslop

Publications

Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity

DOI: http://doi.org/10.1038/s41467-025-65178-0
Journal: Nat Commun
E-pub date: 21 Nov 2025
Authors: SJ Resnick, S Qamar, P Krishna, V Korobeynikov, H Ausserwoger, A Miller, P Esposito, JA Varela, J Sheng, LH Huang, J Nixon-Abell, S Melore, CW Chung, NF Läubli, S Kapsiani, X Li, J Wang, N Zhang, MM Alam, AS Burguete, TC Swayne, Y Chen, Y-C Liao, NA Shneider, M Vendruscolo, TPJ Knowles, CF Kaminski, FS Ruggeri, GS Kaminski Schierle, P St George-Hyslop, A Chavez

Quantifying collective interactions in biomolecular phase separation.

DOI: http://doi.org/10.1038/s41467-025-62437-y
Journal: Nat Commun
E-pub date: 19 Aug 2025
Authors: H Ausserwöger, E de Csilléry, D Qian, G Krainer, TJ Welsh, T Sneideris, TM Franzmann, S Qamar, NA Erkamp, J Nixon-Abell, M Kar, P St George-Hyslop, AA Hyman, S Alberti, RV Pappu, TPJ Knowles

Quantifying collective interactions in biomolecular phase separation

DOI: http://doi.org/10.1101/2023.05.31.543137
Journal:
E-pub date: 4 Jun 2023
Authors: H Ausserwöger, D Qian, G Krainer, E de Csilléry, T Welsh, T Sneideris, T Franzmann, S Qamar, N Erkamp, J Nixon-Abell, M Kar, PS George-Hyslop, A Hyman, S Alberti, R Pappu, T Knowles

Spatially non-uniform condensates emerge from dynamically arrested phase separation.

DOI: http://doi.org/10.1038/s41467-023-36059-1
Journal: Nat Commun
E-pub date: 8 Feb 2023
Authors: NA Erkamp, T Sneideris, H Ausserwöger, D Qian, S Qamar, J Nixon-Abell, P St George-Hyslop, JD Schmit, DA Weitz, TPJ Knowles

Tie-line analysis reveals interactions driving heteromolecular condensate formation

DOI: http://doi.org/10.1103/PhysRevX.12.041038
Journal: Phys Rev X
E-pub date: 30 Dec 2022
Authors: D Qian, T Welsh, N Erkamp, S Qamar, J Nixon-Abell, G Krainer, P St George-Hyslop, T Michaels, T Knowles

Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2.

DOI: http://doi.org/10.15252/embj.2022110777
Journal: EMBO J
E-pub date: 4 Oct 2022
Authors: N Volkmar, CM Gawden-Bone, JC Williamson, J Nixon-Abell, JA West, PH St George-Hyslop, A Kaser, PJ Lehner

Z-α1-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state.

DOI: http://doi.org/10.1126/sciadv.abm2094
Journal: Sci Adv
E-pub date: 8 Apr 2022
Authors: JE Chambers, N Zubkov, M Kubánková, J Nixon-Abell, I Mela, S Abreu, M Schwiening, G Lavarda, I López-Duarte, JA Dickens, T Torres, CF Kaminski, LJ Holt, E Avezov, JA Huntington, PS George-Hyslop, MK Kuimova, SJ Marciniak

Does Soluble TREM2 Protect Against Alzheimer’s Disease?

DOI: http://doi.org/10.3389/fnagi.2021.834697
Journal: Front Aging Neurosci
E-pub date: 1 Aug 2021
Authors: GC Brown, P St George-Hyslop

High Resolution Biomolecular Condensate Phase Diagrams with a Combinatorial Microdroplet Platform

DOI: http://doi.org/10.1101/2020.06.04.132308
Journal:
E-pub date: 7 Jun 2020
Authors: W Arter, R Qi, N Erkamp, G Krainer, K Didi, T Welsh, J Acker, J Nixon-Abell, J Nixon-Abell, S Qamar, J Guillén-Boixet, T Franzmann, D Kuster, A Hyman, A Borodavka, P St George-Hyslop, S Alberti, TPJ Knowles

TET2 Regulates the Neuroinflammatory Response in Microglia.

DOI: http://doi.org/10.1016/j.celrep.2019.09.013
Journal: Cell Rep
E-pub date: 15 Oct 2019
Authors: A Carrillo-Jimenez, Ö Deniz, MV Niklison-Chirou, R Ruiz, K Bezerra-Salomão, V Stratoulias, R Amouroux, PK Yip, A Vilalta, M Cheray, AM Scott-Egerton, E Rivas, K Tayara, I García-Domínguez, J Garcia-Revilla, JC Fernandez-Martin, AM Espinosa-Oliva, X Shen, P St George-Hyslop, GC Brown, P Hajkova, B Joseph, JL Venero, MR Branco, MA Burguillos

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

DOI: http://doi.org/10.2139/ssrn.3312723
Journal:
E-pub date: 1 Jan 2019
Authors: Y-C Liao, M Fernandopulle, G Wang, H Choi, L Hao, CM Drerup, S Qamar, J Nixon-Abell, Y Shen, W Meadows, M Vendruscolo, T Knowles, M Nelson, M Czekalska, G Musteikyte, R Patel, C Stephens, A Pasolli, L Forrest, PS George-Hyslop, J Lippincott-Schwartz, ME Ward

The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration.

DOI: http://doi.org/10.1016/j.brainres.2018.04.036
Journal: Brain Res
E-pub date: 15 Aug 2018
Authors: P St George-Hyslop, JQ Lin, A Miyashita, EC Phillips, S Qamar, SJ Randle, G Wang