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Department
  • Psychiatry
    • Research Theme The Social Brain Lifelong Brain Development and Brain Ageing
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    Dr Isabel Clare

    University Position
    Affiliated Member

    Interests

    I work in the Cambridge Intellectual & Developmental Disabilities Research Group in the Dept. of Psychiatry and as a a senior member of the Enduring Disability and/or Disadvantage clinical theme in the NIHR's CLAHRC East of England. My research interests are focused in three main areas, all relating to people with intellectual or other neurodevelopmental disabilities: a) brain and environment interactions and contributions to everyday decision-making, particularly legally-significant decisions; b) emotional and cognitive functioning, particularly in people with Down Syndrome; c) engaging people with severe intellectual disabilities in neuroscientific investigations.

    Key Publications

    Publications

    Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2022.07.003
    Journal: Neurobiol Aging
    E-pub date: 1 Nov 2022
    Authors: M Grigorova, E Mak, SSG Brown, J Beresford-Webb, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, D Tudorascu, A Cohen, BT Christian, B Ances, BL Handen, CM Laymon, WE Klunk, ICH Clare, AJ Holland, SH Zaman

    Support vector machine learning and diffusion-derived structural networks predict amyloid quantity and cognition in adults with Down’s syndrome.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2022.02.013
    Journal: Neurobiol Aging
    E-pub date: 1 Jul 2022
    Authors: SSG Brown, E Mak, I Clare, M Grigorova, J Beresford-Webb, M Walpert, E Jones, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, D Tudorascu, A Cohen, BT Christian, BL Handen, WE Klunk, DK Menon, PJ Nestor, AJ Holland, SH Zaman

    Amyloid and tau deposition influences cognitive decline in Down syndrome

    DOI: http://doi.org/10.1002/alz.056384
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2021
    Authors: M Grigorova, E Mak, J Beresford‐Webb, SSG Brown, E Jones, I Clare, T Holland, YT Hong, TD Fryer, JP Coles, GB Williams, FI Aigbirhio, BM Ances, BT Christian, BL Handen, WE Klunk, CM Laymon, DL Tudorascu, S Zaman

    Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

    DOI: http://doi.org/10.1093/braincomms/fcaa198
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman