Menu

Department
  • Psychiatry
    • Research Theme The Social Brain Lifelong Brain Development and Brain Ageing
    Back

    Dr Isabel Clare

    University Position
    Affiliated Member

    Interests

    I work in the Cambridge Intellectual & Developmental Disabilities Research Group in the Dept. of Psychiatry and as a a senior member of the Enduring Disability and/or Disadvantage clinical theme in the NIHR's CLAHRC East of England. My research interests are focused in three main areas, all relating to people with intellectual or other neurodevelopmental disabilities: a) brain and environment interactions and contributions to everyday decision-making, particularly legally-significant decisions; b) emotional and cognitive functioning, particularly in people with Down Syndrome; c) engaging people with severe intellectual disabilities in neuroscientific investigations.

    Key Publications

    Publications

    Amyloid and tau deposition influences cognitive and functional decline in Down Syndrome

    DOI: http://doi.org/10.1002/alz.062617
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Jun 2023
    Authors: M Grigorova, E Mak, SSG Brown, J Beresford‐Webb, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DL Tudorascu, AD Cohen, BT Christian, B Ances, BL Handen, CM Laymon, WE Klunk, I Clare, AJ Holland, S Zaman

    Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2022.07.003
    Journal: Neurobiol Aging
    E-pub date: 1 Nov 2022
    Authors: M Grigorova, E Mak, SSG Brown, J Beresford-Webb, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, D Tudorascu, A Cohen, BT Christian, B Ances, BL Handen, CM Laymon, WE Klunk, ICH Clare, AJ Holland, SH Zaman

    Support vector machine learning and diffusion-derived structural networks predict amyloid quantity and cognition in adults with Down’s syndrome.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2022.02.013
    Journal: Neurobiol Aging
    E-pub date: 1 Jul 2022
    Authors: SSG Brown, E Mak, I Clare, M Grigorova, J Beresford-Webb, M Walpert, E Jones, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, D Tudorascu, A Cohen, BT Christian, BL Handen, WE Klunk, DK Menon, PJ Nestor, AJ Holland, SH Zaman

    Amyloid and tau deposition influences cognitive decline in Down syndrome

    DOI: http://doi.org/10.1002/alz.056384
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2021
    Authors: M Grigorova, E Mak, J Beresford‐Webb, SSG Brown, E Jones, I Clare, T Holland, YT Hong, TD Fryer, JP Coles, GB Williams, FI Aigbirhio, BM Ances, BT Christian, BL Handen, WE Klunk, CM Laymon, DL Tudorascu, S Zaman

    The Clinical and Neuropathological Features of Sporadic (Late-Onset) and Genetic Forms of Alzheimer’s Disease.

    DOI: http://doi.org/10.3390/jcm10194582
    Journal: J Clin Med
    E-pub date: 3 Oct 2021
    Authors: T Rujeedawa, E Carrillo Félez, ICH Clare, J Fortea, A Strydom, A-S Rebillat, A Coppus, J Levin, SH Zaman

    Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study.

    DOI: http://doi.org/10.1016/S1474-4422(21)00129-0
    Journal: Lancet Neurol
    E-pub date: 31 Aug 2021
    Authors: M Carmona-Iragui, D Alcolea, I Barroeta, L Videla, L Muñoz, KL Van Pelt, FA Schmitt, DD Lightner, LM Koehl, G Jicha, S Sacco, C Mircher, SE Pape, R Hithersay, ICH Clare, AJ Holland, G Nübling, J Levin, SH Zaman, A Strydom, A-S Rebillat, E Head, R Blesa, A Lleó, J Fortea

    Acute Regression in Down Syndrome.

    DOI: http://doi.org/10.3390/brainsci11081109
    Journal: Brain Sci
    E-pub date: 23 Aug 2021
    Authors: B Handen, I Clare, C Laymon, M Petersen, S Zaman, S O'Bryant, D Minhas, D Tudorascu, S Brown, B Christian

    Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

    DOI: http://doi.org/10.1093/braincomms/fcaa198
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman

    Amnestic and non-amnestic symptoms of dementia: An international study of Alzheimer’s disease in people with Down’s syndrome.

    DOI: http://doi.org/10.1002/gps.5283
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Jun 2020
    Authors: LM Fonseca, C Padilla, E Jones, N Neale, GG Haddad, GP Mattar, E Barros, ICH Clare, GF Busatto, CMC Bottino, MQ Hoexter, AJ Holland, S Zaman