• Pharmacology
  • Research Focus


  • Inflammation
  • Nociception
  • Clinical Conditions

  • Chronic pain
  • Equipment & Techniques

  • Behavioural analysis
  • Calcium imaging
  • Cell culture
  • Fluorescence microscopy
  • Immunohistochemistry
  • Statistical analysis
  • Whole cell patch clamp
  • Back

    Luke Pattison

    University Position
    Research Associate


    My research focuses on the role of proton-sensing G protein-coupled receptors in inflammation.

    Getting a sense of sensation

    Primary mouse sensory neurones expressing a genetically encoded biosensor for detecting intracellular signalling events.

    Key Publications

    Cell-cell interactions in joint pain: rheumatoid arthritis and osteoarthritis.

    Journal: Pain
    E-pub date: 1 Mar 2021
    Authors: LA Pattison, E Krock, CI Svensson, ESJ Smith

    Intraarticular Adeno-Associated Virus Serotype AAV-PHP.S-Mediated Chemogenetic Targeting of Knee-Innervating Dorsal Root Ganglion Neurons Alleviates Inflammatory Pain in Mice.

    Journal: Arthritis Rheumatol
    E-pub date: 1 Oct 2020
    Authors: S Chakrabarti, LA Pattison, B Doleschall, RH Rickman, H Blake, G Callejo, PA Heppenstall, ESJ Smith

    Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α-activated fibroblast-like synoviocytes: an in vitro, coculture model of inflammatory pain.

    Journal: Pain
    E-pub date: 1 Sep 2020
    Authors: S Chakrabarti, Z Hore, LA Pattison, S Lalnunhlimi, CN Bhebhe, G Callejo, DC Bulmer, LS Taams, F Denk, ESJ Smith

    Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel KV6.4 Subunit.

    Journal: Cell Rep
    E-pub date: 21 Jul 2020
    Authors: MC Lee, MS Nahorski, JRF Hockley, VB Lu, G Ison, LA Pattison, G Callejo, K Stouffer, E Fletcher, C Brown, I Drissi, D Wheeler, P Ernfors, D Menon, F Reimann, ESJ Smith, CG Woods

    Evolution of acid nociception: ion channels and receptors for detecting acid.

    Journal: Philos Trans R Soc Lond B Biol Sci
    E-pub date: 11 Nov 2019
    Authors: LA Pattison, G Callejo, E St John Smith


    In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3.

    Journal: Biochem Pharmacol
    E-pub date: 1 Apr 2020
    Authors: G Callejo, LA Pattison, JC Greenhalgh, S Chakrabarti, E Andreopoulou, JRF Hockley, ESJ Smith, T Rahman

    Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.

    Journal: Nat Commun
    E-pub date: 4 Mar 2019
    Authors: VB Lu, J Rievaj, EA O'Flaherty, CA Smith, R Pais, LA Pattison, G Tolhurst, AB Leiter, DC Bulmer, FM Gribble, F Reimann

    Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner.

    Journal: Neuropharmacology
    E-pub date: 1 Dec 2018
    Authors: S Chakrabarti, LA Pattison, K Singhal, JRF Hockley, G Callejo, ESJ Smith