I focus on the investigation of early-stage aggregates of alpha-synuclein in the human brain, which have been found to be a major contributor to the pathogenesis of Parkinson's Disease and other synucleinopathies. We are working on improving our understanding of the macro-level localization of these aggregates across the brain, as well as investigating how they co-localize with different cell-types present in the brain and affect their regular functioning. For this goal, I work mainly on integrating different techniques of microscopy, like super-resolution, confocal and lattice light-sheet microscopy, to enable the visualization and qualitative investigation of the misfolded proteins in disease.
Tyrosine Hydroxylase (TH) positive neurons in human-SNCA over-expressing mouse basal ganglia
