College Peterhouse
Research Focus


  • Alpha Synuclein
  • Alpha-Synucleinopathies
  • Parkinson's Disease
  • Parkinson's Mouse Models
  • Parkinsonism
  • Neurodegeneration
  • Neurodegenerative Brain Disorders
  • Neurodegenerative Dementia
  • Neurodegenerative Disorders
  • Fluorescence Microscopy
  • Microscopy
  • Microscope Development
  • Super-Resolution Microscopy
  • Superresolution Microscopy
  • Proteomics
  • Aggregate-Prone Proteins
  • Protein Aggregation
  • Protein Folding
  • Protein Misfolding
  • Protein Misfolding & Aggregation
  • Protein Misfolding Disorders
  • Synuclein Protein
  • Protein Oligomerisation
  • Clinical Conditions

  • Alzheimer's disease
  • Parkinson's disease
  • Multiple system atrophy
  • Equipment & Techniques

  • Cell culture
  • Confocal microscopy
  • Fluorescence microscopy
  • Immunohistochemistry
  • Microscopy
  • Science Culture

  • CamBRAIN
  • Philosophy of Science
  • Policy Engagement
  • Public Outreach
  • Public Engagement
  • Science Communication
  • Teaching
  • Back

    Jonathan Breiter

    University Position
    PhD student


    I focus on the investigation of early-stage aggregates of alpha-synuclein in the human brain, which have been found to be a major contributor to the pathogenesis of Parkinson's Disease and other synucleinopathies. We are working on improving our understanding of the macro-level localization of these aggregates across the brain, as well as investigating how they co-localize with different cell-types present in the brain and affect their regular functioning. For this goal, I work mainly on integrating different techniques of microscopy, like super-resolution, confocal and lattice light-sheet microscopy, to enable the visualization and qualitative investigation of the misfolded proteins in disease.

    Tyrosine Hydroxylase (TH) positive neurons in human-SNCA over-expressing mouse basal ganglia

    Key Publications

    RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds

    Journal: The Journal of Physical Chemistry B
    Year: 2024
    Authors: Bin Fu, Emma E. Brock, Rebecca Andrews, Jonathan C. Breiter, Ru Tian, Christina E. Toomey, Joanne Lachica, Tammaryn Lashley, Mina Ryten, Nicholas W. Wood, Michele Vendruscolo, Sonia Gandhi, Lucien E. Weiss, Joseph S. Beckwith*, and Steven F. Lee*


    The hibernation-derived compound SUL-138 shifts the mitochondrial proteome towards fatty acid metabolism and prevents cognitive decline and amyloid plaque formation in an Alzheimer’s disease mouse model

    Journal: Alzheimer's Research & Therapy
    Year: 2022
    Authors: Christina F. de Veij Mestdagh, Frank Koopmans, Jonathan C. Breiter, Jaap A. Timmerman, Pieter C. Vogelaar, Guido Krenning, Huibert D. Mansvelder, August B. Smit, Robert H. Henning, Ronald E. van Kesteren