My research focuses on the pathophysiology of ischaemic stroke and the mechanisms underlying subsequent deterioration or recovery, including neuronal damage, tissue inflammation and long-term plasticity processes. In terms of methodology, my approach is characterized by 1) combining brain imaging, both structural and functional (PET and fMRI) and assessment of performance measured using behavioural, cognitive or psychophysical tools; and 2) undertaking parallel studies in stroke patients and animal models, in the latter including microPET, in vitro autoradiographic and post mortem histopathologic techniques to inform the human studies.
