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Department
  • Psychiatry
  • Research Focus

    Keywords

  • 5-HT
  • Adaptive Behaviour
  • Affective Neuroscience
  • Memory Reconsolidation
  • Cognitive Flexibility
  • Associative Learning
  • Compulsivity
  • Clinical Conditions

  • Obsessive compulsive disorder
  • Addiction
  • Anxiety disorders
  • Equipment & Techniques

  • Behavioural analysis
  • Magnetic resonance imaging (MRI)
  • Computational modelling
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    Jonathan Kanen MD PhD

    University Position
    Research Associate

    Interests

    I completed my PhD as a Gates Scholar with Professor Trevor Robbins. Much of my work has centred on the neurochemical modulation of affective and behavioural control, with a special emphasis on serotonin. I seek to connect pharmacological challenge studies with deficits in psychiatric disorders, and have a particular interest in obsessive-compulsive disorder (OCD). I am comparing deficits in behavioural flexibility across compulsive disorders with the goal of informing the refinement of psychiatric classification and treatment. I am also interested in the possibility of revising maladaptive associations by harnessing the process of memory reconsolidation or through the use of psychedelic drugs.

    Key Publications

    Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans

    DOI: http://doi.org/10.1101/2020.12.04.412189
    Journal:
    E-pub date: 13 Jan 2021
    Authors: J Kanen, Q Luo, M Kandroodi, R Cardinal, T Robbins, R Carhart-Harris, HEM den Ouden

    Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans

    DOI: http://doi.org/10.1101/2020.04.26.062463
    Journal:
    E-pub date: 27 Apr 2020
    Authors: J Kanen, A Apergis-Schoute, R Yellowlees, F Arntz, F van der Flier, A Price, R Cardinal, D Christmas, L Clark, B Sahakian, M Crockett, T Robbins

    Extinction during reconsolidation of threat memory diminishes prefrontal cortex involvement.

    DOI: http://doi.org/10.1073/pnas.1320322110
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 10 Dec 2013
    Authors: D Schiller, JW Kanen, JE LeDoux, M-H Monfils, EA Phelps

    Publications

    Harnessing temperament to elucidate the complexities of serotonin function

    DOI: http://doi.org/10.31234/osf.io/gvmuy
    Journal:
    E-pub date: 18 Jul 2021
    Authors: JW Kanen, TW Robbins, IN Trofimova

    Probabilistic reversal learning under acute tryptophan depletion in healthy humans: a conventional analysis.

    DOI: http://doi.org/10.1177/0269881120907991
    Journal: J Psychopharmacol
    E-pub date: 1 May 2020
    Authors: JW Kanen, FE Arntz, R Yellowlees, RN Cardinal, A Price, DM Christmas, BJ Sahakian, AM Apergis-Schoute, TW Robbins

    Effect of tryptophan depletion on conditioned threat memory expression: role of intolerance of uncertainty

    DOI: http://doi.org/10.1101/2020.04.26.062505
    Journal:
    E-pub date: 27 Apr 2020
    Authors: J Kanen, F Arntz, R Yellowlees, D Christmas, A Price, A Apergis-Schoute, B Sahakian, R Cardinal, T Robbins

    Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality

    DOI: http://doi.org/10.1101/789669
    Journal:
    E-pub date: 1 Aug 2019
    Authors: J Kanen, F Arntz, R Yellowlees, R Cardinal, A Price, D Christmas, A Apergis-Schoute, B Sahakian, T Robbins

    Eye-movement intervention enhances extinction via amygdala deactivation

    DOI: http://doi.org/10.1101/282467
    Journal:
    E-pub date: 18 Mar 2018
    Authors: L de Voogd, J Kanen, D Neville, K Roelofs, G Fernández, E Hermans

    Young and old Pavlovian fear memories can be modified with extinction training during reconsolidation in humans.

    DOI: http://doi.org/10.1101/lm.033589.113
    Journal: Learn Mem
    E-pub date: 1 Jul 2014
    Authors: ECK Steinfurth, JW Kanen, CM Raio, RL Clem, RL Huganir, EA Phelps

    The effects of mindfulness-based interventions on sleep disturbance: a meta-analysis

    DOI:
    Journal: Adolescent Psychiatry
    Year: 2015
    Authors: J W Kanen, R Nazir, K Sedky, B K Pradhan

    Association of environmental uncertainty with altered decision-making and learning mechanisms in youths with obsessive-compulsive disorder

    DOI:
    Journal: JAMA Network Open
    Year: 2021
    Authors: Aleya A Marzuki, Ivan Tomić, Samantha Hiu Yan Ip, Julia Gottwald, Jonathan W Kanen, Muzaffer Kaser, Akeem Sule, Anna Conway-Morris, Barbara J Sahakian, Trevor W Robbins

    Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway

    DOI:
    Journal: BMC Medicine
    Year: 2020
    Authors: Qiang Luo, Lingli Zhang, Chu-Chung Huang, Yan Zheng, Jonathan W Kanen, Qi Zhao, Ye Yao, Erin B Quinlan, Tianye Jia, Tobias Banaschewski, Arun LW Bokde, Uli Bromberg, Christian Büchel, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Juliane H Fröhner, Michael N Smolka, Henrik Walter, Robert Whelan, Barbara J Sahakian, Gunter Schumann, Fei Li, Jianfeng Feng, Sylvane Desrivières, Trevor W Robbins, IMAGEN consortium

    What is next for the neurobiology of temperament, personality and psychopathology?

    DOI:
    Journal: Current Opinion in Behavioral Sciences
    Year: 2022
    Authors: Irina Trofimova, Sahil Bajaj, Sergey A Bashkatov, James Blair, Anika Brandt, Raymond CK Chan, Benjamin Clemens, Philip J Corr, Maria Cyniak-Cieciura, Liubov Demidova, Courtney A Filippi, Margarita Garipova, Ute Habel, Nathaniel Haines, Nadja Heym, Kirsty Hunter, Nancy A Jones, Jonathan Kanen, Anna Kirenskaya, Veena Kumari, Sabrina Lenzoni, Simon SY Lui, Avantika Mathur, Neil McNaughton, Krystal D Mize, Erik Mueller, Petra Netter, Katharina Paul, Thomas Plieger, Preethi Premkumar, Adrian Raine, Martin Reuter, Trevor W Robbins, Denis Samylkin, Zinaida Storozheva, William Sulis, Alexander Sumich, Andrey Tkachenko, Emilio A Valadez, Jan Wacker, Lisa Wagels, Ling-ling Wang, Bogdan Zawadzki, Alan D Pickering

    Angiotensin blockade enhances motivational reward learning via enhancing striatal prediction error signaling and frontostriatal communication

    DOI:
    Journal: Molecular Psychiatry
    Year: 2023
    Authors: Ting Xu, Xinqi Zhou, Jonathan W Kanen, Lan Wang, Jialin Li, Zhiyi Chen, Ran Zhang, Guojuan Jiao, Feng Zhou, Weihua Zhao, Shuxia Yao, Benjamin Becker

    Perseveration and Shifting in Obsessive-Compulsive Disorder as a Function of Uncertainty, Punishment, and Serotonergic Medication

    DOI:
    Journal: Biological Psychiatry Global Open Science
    Year: 2023
    Authors: Annemieke M Apergis-Schoute, Febe E van der Flier, Samantha HY Ip, Jonathan W Kanen, Matilde M Vaghi, Naomi A Fineberg, Barbara J Sahakian, Rudolf N Cardinal, Trevor W Robbins

    Computational modeling of reinforcement learning and functional neuroimaging of probabilistic reversal dissociates compulsive behaviors in Gambling and Cocaine Use Disorders

    DOI:
    Journal: British Journal of Psychiatry Open
    Year: in press
    Authors: Katharina Zuhlsdorff, Juan Verdejo-Roman, Luke Clark, Natalia Albein-Urios, Carles Soriano-Mas, Rudolf Cardinal, Trevor Robbins, Jeffrey W Dalley, Antonio Verdejo-Garcia, Jonathan W Kanen

    Common roles for serotonin in rats and humans for computations underlying flexible decision-making

    DOI:
    Journal: Neuropsychopharmacology
    Year: in press
    Authors: Qiang Luo, Jonathan W Kanen, Andrea Bari, Nikolina Skandali, Christelle Langley, Gitte Moos Knudsen, Johan Alsiö, Benjamin U Phillips, Barbara J Sahakian, Rudolf N Cardinal, Trevor W Robbins

    Dynamic neural reconfiguration for distinct strategies during competitive social interactions

    DOI:
    Journal: NeuroImage
    Year: 2022
    Authors: Ruihan Yang, Yina Ma, Bao-Bao Pan, Meghana A Bhatt, Terry Lohrenz, Hua-Guang Gu, Jonathan W Kanen, Colin F Camerer, P Read Montague, Qiang Luo