Joshua Heihre

University Position

PhD student

Interests

My research interests centre on understanding and targeting the molecular and cellular mechanisms of acute brain injury, with a particular focus on mitochondrial dysfunction and neuroinflammation following traumatic brain injury (TBI). My work involves multiomics analysis of brain biofluids (cerebral microdialysate and CSF) in addition to development of in vitro models of TBI to investigate these secondary injury processes, identify biomarkers, and aid clinical translation of novel neuroprotective agents.

Key Publications

Defining metabolic abnormalities in acute human traumatic brain injury with cerebral microdialysis and multimodality monitoring

DOI: https://doi.org/10.1371/journal.pone.0331310
Journal: PLOS ONE
Year: 2025
Authors: Michael S. Baker, Sara Venturini, Caroline Lindblad, Joshua M. Heihre, Ivan Timofeev, Mathew R. Guilfoyle, Peter J. Hutchinson, Keri L.H. Carpenter, Adel Helmy

The microdialysis-derived lactate-pyruvate gradient indicates anaerobic activity after brain injury

DOI: https://doi.org/10.1177/0271678x261485404
Journal: J Cereb Blood Flow Metab
Year: 2026
Authors: Baker MS, Heihre JM, Kuliński TB, Smith CA, Barlas B, Zimphango C, Timofeev I, Baranes K, Carpenter KLH, Kotter M, Guilfoyle MR, Rostami E, Hutchinson P, Helmy A

Publications

A Meta-epidemiologic Analysis of Differences in Treatment-Effect Estimates According to Outcome Scale (GOS vs. GOSE) in Moderate-to-Severe Traumatic Brain Injury Trials

DOI: https://doi.org/10.1007/s12028-026-02634-9
Journal: Neurocrit Care
Year: 2026
Authors: Raccagni NG, Dotti M, Lightfoot YA, Loda R, Baker MS, Heihre JM, Helmy A, Cinotti R, Citerio G.

Recharging the Powerhouse: Mitochondrial Dysfunction and Therapy in Cardiorenal Syndrome Type 4

DOI: https://doi.org/10.1007/s11897-025-00713-0
Journal: Curr Heart Fail Rep
Year: 2025
Authors: Long E, Heihre JM