Dr John Skidmore

University Position

Other

Interests

I am a medicinal chemist and drug discovery leader interested in working collaboratively with academics and industry in order to translate basic neurodegeneration research into potential new treatments. The Alzheimer?s Research UK Cambridge Drug Discovery Institute seeks to generate new validated targets for neurodegenerative disorders and to identify chemical probes and lead compounds for drug development. Our overall objective is to fast-track promising academic science into benefits for people with dementia as quickly as possible. We are focusing on neurodegenerative diseases that cause dementia. These may include Alzheimer?s, vascular dementia, dementia with Lewy bodies, frontotemporal dementia, Parkinson?s dementia and Huntington?s disease. We may also research diseases that share some of the fundamental biological changes involved in particular dementias e.g. motor neurone disease.

Key Publications

The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K)

DOI: http://doi.org/10.1039/d3md00355h
Journal: RSC Med Chem
E-pub date: 18 Oct 2023
Authors: GG Aldred, TPC Rooney, HMG Willems, HK Boffey, C Green, D Winpenny, J Skidmore, JH Clarke, SP Andrews

Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor.

DOI: http://doi.org/10.1039/d3md00039g
Journal: RSC Med Chem
E-pub date: 25 May 2023
Authors: HMG Willems, S Edwards, HK Boffey, SJ Chawner, C Green, T Romero, D Winpenny, J Skidmore, JH Clarke, SP Andrews

The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules.

DOI: http://doi.org/10.1021/acs.jmedchem.2c01693
Journal: J Med Chem
E-pub date: 12 Jan 2023
Authors: TPC Rooney, GG Aldred, HK Boffey, HMG Willems, S Edwards, SJ Chawner, DE Scott, C Green, D Winpenny, J Skidmore, JH Clarke, SP Andrews

Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.

DOI: http://doi.org/10.1021/acs.jmedchem.1c01819
Journal: J Med Chem
E-pub date: 24 Feb 2022
Authors: HK Boffey, TPC Rooney, HMG Willems, S Edwards, C Green, T Howard, D Ogg, T Romero, DE Scott, D Winpenny, J Duce, J Skidmore, JH Clarke, SP Andrews

Systematic Investigation of the Permeability of Androgen Receptor PROTACs.

DOI: http://doi.org/10.1021/acsmedchemlett.0c00194
Journal: ACS Med Chem Lett
E-pub date: 13 Aug 2020
Authors: DE Scott, TPC Rooney, ED Bayle, T Mirza, HMG Willems, JH Clarke, SP Andrews, J Skidmore

Neurodegenerative Diseases and Autophagy

DOI: http://doi.org/10.1016/B978-0-12-811304-2.00011-0
Journal:
E-pub date: 1 Jan 2018
Authors: A Fleming, M Vicinanza, M Renna, C Puri, T Ricketts, J Füllgrabe, A Lopez, SM de Jager, A Ashkenazi, M Pavel, F Licitra, A Caricasole, SP Andrews, J Skidmore, DC Rubinsztein

Publications

Disease phenotypic screening in neuron-glia cocultures identifies blockers of inflammatory neurodegeneration.

DOI: http://doi.org/10.1016/j.isci.2024.109454
Journal: iScience
E-pub date: 19 Apr 2024
Authors: TJY Birkle, HMG Willems, J Skidmore, GC Brown