• Medical Genetics
  • Back

    Dr John Skidmore

    University Position


    I am a medicinal chemist and drug discovery leader interested in working collaboratively with academics and industry in order to translate basic neurodegeneration research into potential new treatments. The Alzheimer?s Research UK Cambridge Drug Discovery Institute seeks to generate new validated targets for neurodegenerative disorders and to identify chemical probes and lead compounds for drug development. Our overall objective is to fast-track promising academic science into benefits for people with dementia as quickly as possible. We are focusing on neurodegenerative diseases that cause dementia. These may include Alzheimer?s, vascular dementia, dementia with Lewy bodies, frontotemporal dementia, Parkinson?s dementia and Huntington?s disease. We may also research diseases that share some of the fundamental biological changes involved in particular dementias e.g. motor neurone disease.

    Key Publications

    The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K)

    Journal: RSC Med Chem
    E-pub date: 18 Oct 2023
    Authors: GG Aldred, TPC Rooney, HMG Willems, HK Boffey, C Green, D Winpenny, J Skidmore, JH Clarke, SP Andrews

    Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor.

    Journal: RSC Med Chem
    E-pub date: 25 May 2023
    Authors: HMG Willems, S Edwards, HK Boffey, SJ Chawner, C Green, T Romero, D Winpenny, J Skidmore, JH Clarke, SP Andrews

    The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules.

    Journal: J Med Chem
    E-pub date: 12 Jan 2023
    Authors: TPC Rooney, GG Aldred, HK Boffey, HMG Willems, S Edwards, SJ Chawner, DE Scott, C Green, D Winpenny, J Skidmore, JH Clarke, SP Andrews

    Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.

    Journal: J Med Chem
    E-pub date: 24 Feb 2022
    Authors: HK Boffey, TPC Rooney, HMG Willems, S Edwards, C Green, T Howard, D Ogg, T Romero, DE Scott, D Winpenny, J Duce, J Skidmore, JH Clarke, SP Andrews

    Systematic Investigation of the Permeability of Androgen Receptor PROTACs.

    Journal: ACS Med Chem Lett
    E-pub date: 13 Aug 2020
    Authors: DE Scott, TPC Rooney, ED Bayle, T Mirza, HMG Willems, JH Clarke, SP Andrews, J Skidmore

    Neurodegenerative Diseases and Autophagy

    E-pub date: 1 Aug 2018
    Authors: A Fleming, M Vicinanza, M Renna, C Puri, T Ricketts, J Füllgrabe, A Lopez, SM de Jager, A Ashkenazi, M Pavel, F Licitra, A Caricasole, SP Andrews, J Skidmore, DC Rubinsztein