Equipment & Techniques
I am a neurologist with an interest in developmental neurobiology and mitochondrial genetics. In the lab, we study how cells and tissues respond to mitochondrial dysfunction, focusing on neural stem cells and the brain. Our goal is to identify novel determinants of tissue-specific phenotypes of mitochondrial and neurodegenerative diseases and to uncover potential therapeutic targets to treat these disorders. We use a wide range of techniques and model systems, but mostly take advantage of the powerful genetics of Drosophila. We combine targeted genetic manipulations with confocal and super-resolution imaging, biosensors, and innovative DamID-based sequencing approaches to study the metabolism, transcriptional and epigenetic changes of different cell-types within the brain of a living organism affected by mitochondrial dysfunction. I also participate in the clinical research programme related to the mitochondrial genetics clinic MitoCamb (https://www-neurosciences.medschl.cam.ac.uk/mitocamb/) in Addenbrooke's CUH NHS Trust.