Dr Keri Carpenter

University Position
Senior Research Associate


Research on human brain chemistry, in brain injury and brain tumour patients. Brain injury is a major cause of disability and death. While some brain injury survivors have good outcomes, others experience varying degrees of disability, which are often life-long, with consequent demands on carers and resources. After the initial event, a complex series of biochemical and biological changes occurs in the hours and days that follow. Brain chemistry is monitored in severely injured patients by means of inserting fine semi-permeable tubes into the brain, a technique called microdialysis. The fluid collected by microdialysis is analysed in various ways. This can reveal information on energy status, metabolism and inflammation in the injured brain. Microdialysis is used routinely to monitor brain injury patients being treated in the Neuro Critical Care Unit, and to support clinical trials investigating new drug treatments or surgical procedures.

Key Publications

Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury.

Journal: Brain
E-pub date: 16 Dec 2021
Authors: J Hermanides, YT Hong, M Trivedi, J Outtrim, F Aigbirhio, PJ Nestor, M Guilfoyle, S Winzeck, VFJ Newcombe, T Das, MM Correia, KLH Carpenter, PJA Hutchinson, AK Gupta, TD Fryer, JD Pickard, DK Menon, JP Coles


Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study.

Journal: Neurosurgery
E-pub date: 1 Jan 2015
Authors: AIR Maas, DK Menon, EW Steyerberg, G Citerio, F Lecky, GT Manley, S Hill, V Legrand, A Sorgner, CENTER-TBI Participants and Investigators